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Elucidating the specificity of non-heparin-based conformational activators of antithrombin for factor Xa inhibition

INTRODUCTION: Antithrombin, the principal inhibitor of coagulation proteases, requires allosteric activation by its physiological cofactor, heparin or heparin sulfate to achieve physiologically permissible rates. This forms the basis of heparin's use as a clinical anticoagulant. However, hepari...

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Detalles Bibliográficos
Autores principales:	Rashid, Qudsia, Abid, Mohammad, Jairajpuri, Mohamad Aman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961949/ https://www.ncbi.nlm.nih.gov/pubmed/24678194 http://dx.doi.org/10.4103/0976-9668.127282

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