Cargando…
Exploring Compound Promiscuity Patterns and Multi-Target Activity Spaces
Compound promiscuity is rationalized as the specific interaction of a small molecule with multiple biological targets (as opposed to non-specific binding events) and represents the molecular basis of polypharmacology, an emerging theme in drug discovery and chemical biology. This concise review focu...
Autores principales: | Hu, Ye, Gupta-Ostermann, Disha, Bajorath, Jürgen |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology (RNCSB) Organization
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962225/ https://www.ncbi.nlm.nih.gov/pubmed/24688751 http://dx.doi.org/10.5936/csbj.201401003 |
Ejemplares similares
-
High-resolution view of compound promiscuity
por: Hu, Ye, et al.
Publicado: (2013) -
Quantifying the Tendency of Therapeutic Target Proteins to Bind Promiscuous or Selective Compounds
por: Hu, Ye, et al.
Publicado: (2015) -
Analyzing compound activity records and promiscuity degrees in light of publication statistics
por: Hu, Ye, et al.
Publicado: (2016) -
Promiscuity progression of bioactive compounds over time
por: Hu, Ye, et al.
Publicado: (2015) -
Determining the Degree of Promiscuity of Extensively Assayed Compounds
por: Jasial, Swarit, et al.
Publicado: (2016)