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Mismatch Negativity of Sad Syllables Is Absent in Patients with Major Depressive Disorder
BACKGROUND: Major depressive disorder (MDD) is an important and highly prevalent mental disorder characterized by anhedonia and a lack of interest in everyday activities. Additionally, patients with MDD appear to have deficits in various cognitive abilities. Although a number of studies investigatin...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962367/ https://www.ncbi.nlm.nih.gov/pubmed/24658084 http://dx.doi.org/10.1371/journal.pone.0091995 |
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author | Pang, Xiaomei Xu, Jing Chang, Yi Tang, Di Zheng, Ya Liu, Yanhua Sun, Yiming |
author_facet | Pang, Xiaomei Xu, Jing Chang, Yi Tang, Di Zheng, Ya Liu, Yanhua Sun, Yiming |
author_sort | Pang, Xiaomei |
collection | PubMed |
description | BACKGROUND: Major depressive disorder (MDD) is an important and highly prevalent mental disorder characterized by anhedonia and a lack of interest in everyday activities. Additionally, patients with MDD appear to have deficits in various cognitive abilities. Although a number of studies investigating the central auditory processing of low-level sound features in patients with MDD have demonstrated that this population exhibits impairments in automatic processing, the influence of emotional voice processing has yet to be addressed. To explore the automatic processing of emotional prosodies in patients with MDD, we analyzed the ability to detect automatic changes using event-related potentials (ERPs). METHOD: This study included 18 patients with MDD and 22 age- and sex-matched healthy controls. Subjects were instructed to watch a silent movie but to ignore the afferent acoustic emotional prosodies presented to both ears while continuous electroencephalographic activity was synchronously recorded. Prosodies included meaningless syllables, such as “dada” spoken with happy, angry, sad, or neutral tones. The mean amplitudes of the ERPs elicited by emotional stimuli and the peak latency of the emotional differential waveforms were analyzed. RESULTS: The sad MMN was absent in patients with MDD, whereas the happy and angry MMN components were similar across groups. The abnormal sad emotional MMN component was not significantly correlated with the HRSD-17 and HAMA scores, respectively. CONCLUSION: The data indicate that patients with MDD are impaired in their ability to automatically process sad prosody, whereas their ability to process happy and angry prosodies remains normal. The dysfunctional sad emotion-related MMN in patients with MDD were not correlated with depression symptoms. The blunted MMN of sad prosodies could be considered a trait of MDD. |
format | Online Article Text |
id | pubmed-3962367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39623672014-03-24 Mismatch Negativity of Sad Syllables Is Absent in Patients with Major Depressive Disorder Pang, Xiaomei Xu, Jing Chang, Yi Tang, Di Zheng, Ya Liu, Yanhua Sun, Yiming PLoS One Research Article BACKGROUND: Major depressive disorder (MDD) is an important and highly prevalent mental disorder characterized by anhedonia and a lack of interest in everyday activities. Additionally, patients with MDD appear to have deficits in various cognitive abilities. Although a number of studies investigating the central auditory processing of low-level sound features in patients with MDD have demonstrated that this population exhibits impairments in automatic processing, the influence of emotional voice processing has yet to be addressed. To explore the automatic processing of emotional prosodies in patients with MDD, we analyzed the ability to detect automatic changes using event-related potentials (ERPs). METHOD: This study included 18 patients with MDD and 22 age- and sex-matched healthy controls. Subjects were instructed to watch a silent movie but to ignore the afferent acoustic emotional prosodies presented to both ears while continuous electroencephalographic activity was synchronously recorded. Prosodies included meaningless syllables, such as “dada” spoken with happy, angry, sad, or neutral tones. The mean amplitudes of the ERPs elicited by emotional stimuli and the peak latency of the emotional differential waveforms were analyzed. RESULTS: The sad MMN was absent in patients with MDD, whereas the happy and angry MMN components were similar across groups. The abnormal sad emotional MMN component was not significantly correlated with the HRSD-17 and HAMA scores, respectively. CONCLUSION: The data indicate that patients with MDD are impaired in their ability to automatically process sad prosody, whereas their ability to process happy and angry prosodies remains normal. The dysfunctional sad emotion-related MMN in patients with MDD were not correlated with depression symptoms. The blunted MMN of sad prosodies could be considered a trait of MDD. Public Library of Science 2014-03-21 /pmc/articles/PMC3962367/ /pubmed/24658084 http://dx.doi.org/10.1371/journal.pone.0091995 Text en © 2014 Pang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Pang, Xiaomei Xu, Jing Chang, Yi Tang, Di Zheng, Ya Liu, Yanhua Sun, Yiming Mismatch Negativity of Sad Syllables Is Absent in Patients with Major Depressive Disorder |
title | Mismatch Negativity of Sad Syllables Is Absent in Patients with Major Depressive Disorder |
title_full | Mismatch Negativity of Sad Syllables Is Absent in Patients with Major Depressive Disorder |
title_fullStr | Mismatch Negativity of Sad Syllables Is Absent in Patients with Major Depressive Disorder |
title_full_unstemmed | Mismatch Negativity of Sad Syllables Is Absent in Patients with Major Depressive Disorder |
title_short | Mismatch Negativity of Sad Syllables Is Absent in Patients with Major Depressive Disorder |
title_sort | mismatch negativity of sad syllables is absent in patients with major depressive disorder |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962367/ https://www.ncbi.nlm.nih.gov/pubmed/24658084 http://dx.doi.org/10.1371/journal.pone.0091995 |
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