Quantification and Kinetic Analysis of Grb2-EGFR Interaction on Micro-Patterned Surfaces for the Characterization of EGFR-Modulating Substances

The identification of the epidermal growth factor receptor (EGFR) as an oncogene has led to the development of several anticancer therapeutics directed against this receptor tyrosine kinase. However, drug resistance and low efficacy remain a severe challenge, and have led to a demand for novel syste...

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Detalles Bibliográficos
Autores principales: Lanzerstorfer, Peter, Borgmann, Daniela, Schütz, Gerhard, Winkler, Stephan M., Höglinger, Otmar, Weghuber, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962377/
https://www.ncbi.nlm.nih.gov/pubmed/24658383
http://dx.doi.org/10.1371/journal.pone.0092151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962377/
https://www.ncbi.nlm.nih.gov/pubmed/24658383
http://dx.doi.org/10.1371/journal.pone.0092151

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