EphA4 Activation of c-Abl Mediates Synaptic Loss and LTP Blockade Caused by Amyloid-β Oligomers

The early stages of Alzheimer's disease are characterised by impaired synaptic plasticity and synapse loss. Here, we show that amyloid-β oligomers (AβOs) activate the c-Abl kinase in dendritic spines of cultured hippocampal neurons and that c-Abl kinase activity is required for AβOs-induced syn...

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Detalles Bibliográficos
Autores principales: M. Vargas, Lina, Leal, Nancy, Estrada, Lisbell D., González, Adrian, Serrano, Felipe, Araya, Katherine, Gysling, Katia, Inestrosa, Nibaldo C., Pasquale, Elena B., Alvarez, Alejandra R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962387/
https://www.ncbi.nlm.nih.gov/pubmed/24658113
http://dx.doi.org/10.1371/journal.pone.0092309

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