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Inhibiting Spinal Neuron-Astrocytic Activation Correlates with Synergistic Analgesia of Dexmedetomidine and Ropivacaine

BACKGROUND: This study aims to identify that intrathecal (i.t.) injection of dexmedetomidine (Dex) and ropivacaine (Ropi) induces synergistic analgesia on chronic inflammatory pain and is accompanied with corresponding “neuron-astrocytic” alterations. METHODS: Male, adult Sprague-Dawley rats were ra...

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Detalles Bibliográficos
Autores principales:	Wu, Huang-Hui, Yin, Jun-Bin, Zhang, Ting, Cui, Yuan-Yuan, Dong, Yu-Lin, Chen, Guo-Zhong, Wang, Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962412/ https://www.ncbi.nlm.nih.gov/pubmed/24658263 http://dx.doi.org/10.1371/journal.pone.0092374

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