The IclR-Family Regulator BapR Controls Biofilm Formation in B. cenocepacia H111

In Burkholderia cenocepacia H111, the large surface protein BapA plays a crucial role in the formation of highly structured communities, known as biofilms. We have recently demonstrated that quorum sensing (QS) is necessary for the maximal expression of bapA. In this study we identify BapR, a protei...

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Detalles Bibliográficos
Autores principales: Aguilar, Claudio, Schmid, Nadine, Lardi, Martina, Pessi, Gabriella, Eberl, Leo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962473/
https://www.ncbi.nlm.nih.gov/pubmed/24658785
http://dx.doi.org/10.1371/journal.pone.0092920
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author Aguilar, Claudio
Schmid, Nadine
Lardi, Martina
Pessi, Gabriella
Eberl, Leo
author_facet Aguilar, Claudio
Schmid, Nadine
Lardi, Martina
Pessi, Gabriella
Eberl, Leo
author_sort Aguilar, Claudio
collection PubMed
description In Burkholderia cenocepacia H111, the large surface protein BapA plays a crucial role in the formation of highly structured communities, known as biofilms. We have recently demonstrated that quorum sensing (QS) is necessary for the maximal expression of bapA. In this study we identify BapR, a protein from the IclR family of transcriptional regulators that, in conjunction with QS, controls biofilm formation by affecting the expression of bapA. We present evidence that, in addition to bapA, BapR influences the expression of extracellular proteases, swimming motility and has a profound impact in the incidence of persister cells, making this regulator an interesting target for persister cells and biofilm eradication.
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spelling pubmed-39624732014-03-24 The IclR-Family Regulator BapR Controls Biofilm Formation in B. cenocepacia H111 Aguilar, Claudio Schmid, Nadine Lardi, Martina Pessi, Gabriella Eberl, Leo PLoS One Research Article In Burkholderia cenocepacia H111, the large surface protein BapA plays a crucial role in the formation of highly structured communities, known as biofilms. We have recently demonstrated that quorum sensing (QS) is necessary for the maximal expression of bapA. In this study we identify BapR, a protein from the IclR family of transcriptional regulators that, in conjunction with QS, controls biofilm formation by affecting the expression of bapA. We present evidence that, in addition to bapA, BapR influences the expression of extracellular proteases, swimming motility and has a profound impact in the incidence of persister cells, making this regulator an interesting target for persister cells and biofilm eradication. Public Library of Science 2014-03-21 /pmc/articles/PMC3962473/ /pubmed/24658785 http://dx.doi.org/10.1371/journal.pone.0092920 Text en © 2014 Aguilar et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Aguilar, Claudio
Schmid, Nadine
Lardi, Martina
Pessi, Gabriella
Eberl, Leo
The IclR-Family Regulator BapR Controls Biofilm Formation in B. cenocepacia H111
title The IclR-Family Regulator BapR Controls Biofilm Formation in B. cenocepacia H111
title_full The IclR-Family Regulator BapR Controls Biofilm Formation in B. cenocepacia H111
title_fullStr The IclR-Family Regulator BapR Controls Biofilm Formation in B. cenocepacia H111
title_full_unstemmed The IclR-Family Regulator BapR Controls Biofilm Formation in B. cenocepacia H111
title_short The IclR-Family Regulator BapR Controls Biofilm Formation in B. cenocepacia H111
title_sort iclr-family regulator bapr controls biofilm formation in b. cenocepacia h111
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962473/
https://www.ncbi.nlm.nih.gov/pubmed/24658785
http://dx.doi.org/10.1371/journal.pone.0092920
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