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Cross-Reactivity of Peanut Allergens

Peanut seeds are currently widely used as source of human food ingredients in the United States of America and in European countries due to their high quality protein and oil content. This article describes the classification and molecular biology of peanut seed allergens with particular reference t...

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Detalles Bibliográficos
Autores principales: Bublin, Merima, Breiteneder, Heimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962743/
https://www.ncbi.nlm.nih.gov/pubmed/24554241
http://dx.doi.org/10.1007/s11882-014-0426-8
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author Bublin, Merima
Breiteneder, Heimo
author_facet Bublin, Merima
Breiteneder, Heimo
author_sort Bublin, Merima
collection PubMed
description Peanut seeds are currently widely used as source of human food ingredients in the United States of America and in European countries due to their high quality protein and oil content. This article describes the classification and molecular biology of peanut seed allergens with particular reference to their cross-reactivities. Currently, the IUIS allergen nomenclature subcommittee accepts 12 peanut allergens. Two allergens belong to the cupin and four to the prolamin superfamily, and six are distributed among profilins, Bet v 1-like proteins, oleosins, and defensins. Clinical observations frequently report an association of peanut allergy with allergies to legumes, tree nuts, seeds, fruits and pollen. Molecular cross-reactivity has been described between members of the Bet v 1-like proteins, the non-specific lipid transfer proteins, and the profilins. This review also addresses the less well-studied cross-reactivity between cupin and prolamin allergens of peanuts and of other plant food sources and the recently discovered cross-reactivity between peanut allergens of unrelated protein families.
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spelling pubmed-39627432014-03-24 Cross-Reactivity of Peanut Allergens Bublin, Merima Breiteneder, Heimo Curr Allergy Asthma Rep Allergens (RK Bush and Ja Woodfolk, Section Editors) Peanut seeds are currently widely used as source of human food ingredients in the United States of America and in European countries due to their high quality protein and oil content. This article describes the classification and molecular biology of peanut seed allergens with particular reference to their cross-reactivities. Currently, the IUIS allergen nomenclature subcommittee accepts 12 peanut allergens. Two allergens belong to the cupin and four to the prolamin superfamily, and six are distributed among profilins, Bet v 1-like proteins, oleosins, and defensins. Clinical observations frequently report an association of peanut allergy with allergies to legumes, tree nuts, seeds, fruits and pollen. Molecular cross-reactivity has been described between members of the Bet v 1-like proteins, the non-specific lipid transfer proteins, and the profilins. This review also addresses the less well-studied cross-reactivity between cupin and prolamin allergens of peanuts and of other plant food sources and the recently discovered cross-reactivity between peanut allergens of unrelated protein families. Springer US 2014-02-20 2014 /pmc/articles/PMC3962743/ /pubmed/24554241 http://dx.doi.org/10.1007/s11882-014-0426-8 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Allergens (RK Bush and Ja Woodfolk, Section Editors)
Bublin, Merima
Breiteneder, Heimo
Cross-Reactivity of Peanut Allergens
title Cross-Reactivity of Peanut Allergens
title_full Cross-Reactivity of Peanut Allergens
title_fullStr Cross-Reactivity of Peanut Allergens
title_full_unstemmed Cross-Reactivity of Peanut Allergens
title_short Cross-Reactivity of Peanut Allergens
title_sort cross-reactivity of peanut allergens
topic Allergens (RK Bush and Ja Woodfolk, Section Editors)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962743/
https://www.ncbi.nlm.nih.gov/pubmed/24554241
http://dx.doi.org/10.1007/s11882-014-0426-8
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