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Coronin-1 is a neurotrophin endosomal effector required for developmental competition for survival
Retrograde communication from axonal targets to neuronal cell bodies is critical for both development and function of the nervous system. Much progress has been made in recent years linking long-distance, retrograde signaling to a signaling endosome, yet the mechanisms governing the trafficking and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962792/ https://www.ncbi.nlm.nih.gov/pubmed/24270184 http://dx.doi.org/10.1038/nn.3593 |
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author | Suo, Dong Park, Juyeon Harrington, Anthony W. Zweifel, Larry S. Mihalas, Stefan Deppmann, Christopher D. |
author_facet | Suo, Dong Park, Juyeon Harrington, Anthony W. Zweifel, Larry S. Mihalas, Stefan Deppmann, Christopher D. |
author_sort | Suo, Dong |
collection | PubMed |
description | Retrograde communication from axonal targets to neuronal cell bodies is critical for both development and function of the nervous system. Much progress has been made in recent years linking long-distance, retrograde signaling to a signaling endosome, yet the mechanisms governing the trafficking and signaling of these endosomes remain mainly uncharacterized. Here we report that in mouse sympathetic neurons the target-derived NGF-TrkA signaling endosome, upon arrival at the cell body, induces the expression and recruitment of a novel effector protein known as Coronin-1. In the absence of Coronin-1, the NGF-TrkA signaling endosome fuses to lysosomes 6–10 fold faster than when Coronin-1 is intact. We also define a novel Coronin-1-dependent trafficking event where signaling endosomes recycle and re-internalize upon arrival at the cell body. Beyond influencing endosomal trafficking, Coronin-1 is also required for several NGF-TrkA dependent-signaling events including calcium release, calcineurin activation, and CREB phosphorylation. These results establish Coronin-1 as an essential component of a novel feedback loop mediating NGF-TrkA endosome stability, recycling, and signaling as a critical mechanism governing developmental competition for survival. |
format | Online Article Text |
id | pubmed-3962792 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
record_format | MEDLINE/PubMed |
spelling | pubmed-39627922014-07-01 Coronin-1 is a neurotrophin endosomal effector required for developmental competition for survival Suo, Dong Park, Juyeon Harrington, Anthony W. Zweifel, Larry S. Mihalas, Stefan Deppmann, Christopher D. Nat Neurosci Article Retrograde communication from axonal targets to neuronal cell bodies is critical for both development and function of the nervous system. Much progress has been made in recent years linking long-distance, retrograde signaling to a signaling endosome, yet the mechanisms governing the trafficking and signaling of these endosomes remain mainly uncharacterized. Here we report that in mouse sympathetic neurons the target-derived NGF-TrkA signaling endosome, upon arrival at the cell body, induces the expression and recruitment of a novel effector protein known as Coronin-1. In the absence of Coronin-1, the NGF-TrkA signaling endosome fuses to lysosomes 6–10 fold faster than when Coronin-1 is intact. We also define a novel Coronin-1-dependent trafficking event where signaling endosomes recycle and re-internalize upon arrival at the cell body. Beyond influencing endosomal trafficking, Coronin-1 is also required for several NGF-TrkA dependent-signaling events including calcium release, calcineurin activation, and CREB phosphorylation. These results establish Coronin-1 as an essential component of a novel feedback loop mediating NGF-TrkA endosome stability, recycling, and signaling as a critical mechanism governing developmental competition for survival. 2013-11-24 2014-01 /pmc/articles/PMC3962792/ /pubmed/24270184 http://dx.doi.org/10.1038/nn.3593 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Suo, Dong Park, Juyeon Harrington, Anthony W. Zweifel, Larry S. Mihalas, Stefan Deppmann, Christopher D. Coronin-1 is a neurotrophin endosomal effector required for developmental competition for survival |
title | Coronin-1 is a neurotrophin endosomal effector required for developmental competition for survival |
title_full | Coronin-1 is a neurotrophin endosomal effector required for developmental competition for survival |
title_fullStr | Coronin-1 is a neurotrophin endosomal effector required for developmental competition for survival |
title_full_unstemmed | Coronin-1 is a neurotrophin endosomal effector required for developmental competition for survival |
title_short | Coronin-1 is a neurotrophin endosomal effector required for developmental competition for survival |
title_sort | coronin-1 is a neurotrophin endosomal effector required for developmental competition for survival |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962792/ https://www.ncbi.nlm.nih.gov/pubmed/24270184 http://dx.doi.org/10.1038/nn.3593 |
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