Epigenetic Biomarkers: Potential Applications in Gastrointestinal Cancers

Genetics and epigenetics coregulate the cancer initiation and progression. Epigenetic mechanisms include DNA methylation, histone modification, chromatin remodeling, and noncoding RNAs. Aberrant epigenetic modifications play a fundamental role in the formation of gastrointestinal cancers. Advances i...

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Detalles Bibliográficos
Autores principales: Li, Jiaqiu, Jin, Hongchuan, Wang, Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963109/
https://www.ncbi.nlm.nih.gov/pubmed/24729878
http://dx.doi.org/10.1155/2014/464015
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author Li, Jiaqiu
Jin, Hongchuan
Wang, Xian
author_facet Li, Jiaqiu
Jin, Hongchuan
Wang, Xian
author_sort Li, Jiaqiu
collection PubMed
description Genetics and epigenetics coregulate the cancer initiation and progression. Epigenetic mechanisms include DNA methylation, histone modification, chromatin remodeling, and noncoding RNAs. Aberrant epigenetic modifications play a fundamental role in the formation of gastrointestinal cancers. Advances in epigenetics offer a better understanding of the carcinogenesis and provide new insights into the discovery of biomarkers for diagnosis, and prognosis prediction of human cancers. This review aims to overview the epigenetic aberrance and the clinical applications as biomarkers in gastrointestinal cancers mainly gastric cancer and colorectal cancer.
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spelling pubmed-39631092014-04-13 Epigenetic Biomarkers: Potential Applications in Gastrointestinal Cancers Li, Jiaqiu Jin, Hongchuan Wang, Xian ISRN Gastroenterol Review Article Genetics and epigenetics coregulate the cancer initiation and progression. Epigenetic mechanisms include DNA methylation, histone modification, chromatin remodeling, and noncoding RNAs. Aberrant epigenetic modifications play a fundamental role in the formation of gastrointestinal cancers. Advances in epigenetics offer a better understanding of the carcinogenesis and provide new insights into the discovery of biomarkers for diagnosis, and prognosis prediction of human cancers. This review aims to overview the epigenetic aberrance and the clinical applications as biomarkers in gastrointestinal cancers mainly gastric cancer and colorectal cancer. Hindawi Publishing Corporation 2014-03-06 /pmc/articles/PMC3963109/ /pubmed/24729878 http://dx.doi.org/10.1155/2014/464015 Text en Copyright © 2014 Jiaqiu Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Jiaqiu
Jin, Hongchuan
Wang, Xian
Epigenetic Biomarkers: Potential Applications in Gastrointestinal Cancers
title Epigenetic Biomarkers: Potential Applications in Gastrointestinal Cancers
title_full Epigenetic Biomarkers: Potential Applications in Gastrointestinal Cancers
title_fullStr Epigenetic Biomarkers: Potential Applications in Gastrointestinal Cancers
title_full_unstemmed Epigenetic Biomarkers: Potential Applications in Gastrointestinal Cancers
title_short Epigenetic Biomarkers: Potential Applications in Gastrointestinal Cancers
title_sort epigenetic biomarkers: potential applications in gastrointestinal cancers
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963109/
https://www.ncbi.nlm.nih.gov/pubmed/24729878
http://dx.doi.org/10.1155/2014/464015
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AT jinhongchuan epigeneticbiomarkerspotentialapplicationsingastrointestinalcancers
AT wangxian epigeneticbiomarkerspotentialapplicationsingastrointestinalcancers

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