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Obesity as a Consequence of Gut Bacteria and Diet Interactions

Obesity is a major public health concern, caused by a combination of increased consumption of energy-dense foods and reduced physical activity, with contributions from host genetics, environment, and adipose tissue inflammation. In recent years, the gut microbiome has also been found to be implicate...

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Autores principales: Kotzampassi, Katerina, Giamarellos-Bourboulis, Evangelos J., Stavrou, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963190/
https://www.ncbi.nlm.nih.gov/pubmed/24977101
http://dx.doi.org/10.1155/2014/651895
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author Kotzampassi, Katerina
Giamarellos-Bourboulis, Evangelos J.
Stavrou, George
author_facet Kotzampassi, Katerina
Giamarellos-Bourboulis, Evangelos J.
Stavrou, George
author_sort Kotzampassi, Katerina
collection PubMed
description Obesity is a major public health concern, caused by a combination of increased consumption of energy-dense foods and reduced physical activity, with contributions from host genetics, environment, and adipose tissue inflammation. In recent years, the gut microbiome has also been found to be implicated and augmented research in mice and humans have attributed to it both the manifestation and/or exacerbation of this major epidemic and vice versa. At the experimental level, analysis of fecal samples revealed a potential link between obesity and alterations in the gut flora (drop in Bacteroidetes and increase in Firmicutes), the specific gut microbiome being associated with the obese phenotype. Conventionally raised mice were found to have over 40% more total body fat compared with those raised under germ-free conditions, while conventionalization of germ-free mice resulted in a significant increase in total body fat. Similarly, the sparse data in humans supports the fact that fat storage is favoured by the presence of the gut microbiota, through a multifaceted mechanism. Efforts to identify new therapeutic strategies to modulate gut microbiota would be of high priority for public health, and to date, probiotics and/or prebiotics seem to be the most effective tools.
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spelling pubmed-39631902014-06-29 Obesity as a Consequence of Gut Bacteria and Diet Interactions Kotzampassi, Katerina Giamarellos-Bourboulis, Evangelos J. Stavrou, George ISRN Obes Review Article Obesity is a major public health concern, caused by a combination of increased consumption of energy-dense foods and reduced physical activity, with contributions from host genetics, environment, and adipose tissue inflammation. In recent years, the gut microbiome has also been found to be implicated and augmented research in mice and humans have attributed to it both the manifestation and/or exacerbation of this major epidemic and vice versa. At the experimental level, analysis of fecal samples revealed a potential link between obesity and alterations in the gut flora (drop in Bacteroidetes and increase in Firmicutes), the specific gut microbiome being associated with the obese phenotype. Conventionally raised mice were found to have over 40% more total body fat compared with those raised under germ-free conditions, while conventionalization of germ-free mice resulted in a significant increase in total body fat. Similarly, the sparse data in humans supports the fact that fat storage is favoured by the presence of the gut microbiota, through a multifaceted mechanism. Efforts to identify new therapeutic strategies to modulate gut microbiota would be of high priority for public health, and to date, probiotics and/or prebiotics seem to be the most effective tools. Hindawi Publishing Corporation 2014-03-06 /pmc/articles/PMC3963190/ /pubmed/24977101 http://dx.doi.org/10.1155/2014/651895 Text en Copyright © 2014 Katerina Kotzampassi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kotzampassi, Katerina
Giamarellos-Bourboulis, Evangelos J.
Stavrou, George
Obesity as a Consequence of Gut Bacteria and Diet Interactions
title Obesity as a Consequence of Gut Bacteria and Diet Interactions
title_full Obesity as a Consequence of Gut Bacteria and Diet Interactions
title_fullStr Obesity as a Consequence of Gut Bacteria and Diet Interactions
title_full_unstemmed Obesity as a Consequence of Gut Bacteria and Diet Interactions
title_short Obesity as a Consequence of Gut Bacteria and Diet Interactions
title_sort obesity as a consequence of gut bacteria and diet interactions
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963190/
https://www.ncbi.nlm.nih.gov/pubmed/24977101
http://dx.doi.org/10.1155/2014/651895
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