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Timing of Single-Neuron and Local Field Potential Responses in the Human Medial Temporal Lobe

The relationship between the firing of single cells and local field potentials (LFPs) has received increasing attention, with studies in animals [1–11] and humans [12–14]. Recordings in the human medial temporal lobe (MTL) have demonstrated the existence of neurons with selective and invariant respo...

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Detalles Bibliográficos
Autores principales: Rey, Hernan Gonzalo, Fried, Itzhak, Quian Quiroga, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963414/
https://www.ncbi.nlm.nih.gov/pubmed/24462002
http://dx.doi.org/10.1016/j.cub.2013.12.004
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author Rey, Hernan Gonzalo
Fried, Itzhak
Quian Quiroga, Rodrigo
author_facet Rey, Hernan Gonzalo
Fried, Itzhak
Quian Quiroga, Rodrigo
author_sort Rey, Hernan Gonzalo
collection PubMed
description The relationship between the firing of single cells and local field potentials (LFPs) has received increasing attention, with studies in animals [1–11] and humans [12–14]. Recordings in the human medial temporal lobe (MTL) have demonstrated the existence of neurons with selective and invariant responses [15], with a relatively late but precise response onset around 300 ms after stimulus presentation [16–18] and firing only upon conscious recognition of the stimulus [19]. This represents a much later onset than expected from direct projections from inferotemporal cortex [16, 18]. The neural mechanisms underlying this onset remain unclear. To address this issue, we performed a joint analysis of single-cell and LFP responses during a visual recognition task. Single-neuron responses were preceded by a global LFP deflection in the theta range. In addition, there was a local and stimulus-specific increase in the single-trial gamma power. These LFP responses correlated with conscious recognition. The timing of the neurons’ firing was phase locked to these LFP responses. We propose that whereas the gamma phase locking reflects the activation of local networks encoding particular recognized stimuli, the theta phase locking reflects a global activation that provides a temporal window for processing consciously perceived stimuli in the MTL.
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spelling pubmed-39634142014-03-24 Timing of Single-Neuron and Local Field Potential Responses in the Human Medial Temporal Lobe Rey, Hernan Gonzalo Fried, Itzhak Quian Quiroga, Rodrigo Curr Biol Report The relationship between the firing of single cells and local field potentials (LFPs) has received increasing attention, with studies in animals [1–11] and humans [12–14]. Recordings in the human medial temporal lobe (MTL) have demonstrated the existence of neurons with selective and invariant responses [15], with a relatively late but precise response onset around 300 ms after stimulus presentation [16–18] and firing only upon conscious recognition of the stimulus [19]. This represents a much later onset than expected from direct projections from inferotemporal cortex [16, 18]. The neural mechanisms underlying this onset remain unclear. To address this issue, we performed a joint analysis of single-cell and LFP responses during a visual recognition task. Single-neuron responses were preceded by a global LFP deflection in the theta range. In addition, there was a local and stimulus-specific increase in the single-trial gamma power. These LFP responses correlated with conscious recognition. The timing of the neurons’ firing was phase locked to these LFP responses. We propose that whereas the gamma phase locking reflects the activation of local networks encoding particular recognized stimuli, the theta phase locking reflects a global activation that provides a temporal window for processing consciously perceived stimuli in the MTL. Cell Press 2014-02-03 /pmc/articles/PMC3963414/ /pubmed/24462002 http://dx.doi.org/10.1016/j.cub.2013.12.004 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Report
Rey, Hernan Gonzalo
Fried, Itzhak
Quian Quiroga, Rodrigo
Timing of Single-Neuron and Local Field Potential Responses in the Human Medial Temporal Lobe
title Timing of Single-Neuron and Local Field Potential Responses in the Human Medial Temporal Lobe
title_full Timing of Single-Neuron and Local Field Potential Responses in the Human Medial Temporal Lobe
title_fullStr Timing of Single-Neuron and Local Field Potential Responses in the Human Medial Temporal Lobe
title_full_unstemmed Timing of Single-Neuron and Local Field Potential Responses in the Human Medial Temporal Lobe
title_short Timing of Single-Neuron and Local Field Potential Responses in the Human Medial Temporal Lobe
title_sort timing of single-neuron and local field potential responses in the human medial temporal lobe
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963414/
https://www.ncbi.nlm.nih.gov/pubmed/24462002
http://dx.doi.org/10.1016/j.cub.2013.12.004
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