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Direct Visualization of CHIP-Mediated Degradation of Alpha-Synuclein In Vivo: Implications for PD Therapeutics

Parkinson's disease is a neurodegenerative disorder characterized by Lewy bodies, a pathological hallmark comprised mostly of aggregated alpha synuclein. Accumulating evidence demonstrates the association of smaller oligomeric aggregates to disease etiology and many therapeutic approaches are a...

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Detalles Bibliográficos
Autores principales:	Dimant, Hemi, Zhu, Liya, Kibuuka, Laura N., Fan, Zhanyun, Hyman, Bradley T., McLean, Pamela J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963877/ https://www.ncbi.nlm.nih.gov/pubmed/24664141 http://dx.doi.org/10.1371/journal.pone.0092098

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