FOXO4-Knockdown Suppresses Oxidative Stress-Induced Apoptosis of Early Pro-Angiogenic Cells and Augments Their Neovascularization Capacities in Ischemic Limbs

The effects of therapeutic angiogenesis by intramuscular injection of early pro-angiogenic cells (EPCs) to ischemic limbs are unsatisfactory. Oxidative stress in the ischemic limbs may accelerate apoptosis of injected EPCs, leading to less neovascularization. Forkhead transcription factor 4 (FOXO4)...

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Detalles Bibliográficos
Autores principales: Nakayoshi, Takaharu, Sasaki, Ken-ichiro, Kajimoto, Hidemi, Koiwaya, Hiroshi, Ohtsuka, Masanori, Ueno, Takafumi, Chibana, Hidetoshi, Itaya, Naoki, Sasaki, Masahiro, Yokoyama, Shinji, Fukumoto, Yoshihiro, Imaizumi, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963928/
https://www.ncbi.nlm.nih.gov/pubmed/24663349
http://dx.doi.org/10.1371/journal.pone.0092626

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