Cargando…
Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug
Current chemotherapy for glioma is rarely satisfactory due to low therapeutic efficiency and systemic side effects. We have developed a glioma-targeted drug delivery system based on graphene oxide. Targeted peptide chlorotoxin-conjugated graphene oxide (CTX-GO) sheets were successfully synthesized a...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964034/ https://www.ncbi.nlm.nih.gov/pubmed/24672236 http://dx.doi.org/10.2147/IJN.S58783 |
_version_ | 1782308591774990336 |
---|---|
author | Wang, Hao Gu, Wei Xiao, Ning Ye, Ling Xu, Qunyuan |
author_facet | Wang, Hao Gu, Wei Xiao, Ning Ye, Ling Xu, Qunyuan |
author_sort | Wang, Hao |
collection | PubMed |
description | Current chemotherapy for glioma is rarely satisfactory due to low therapeutic efficiency and systemic side effects. We have developed a glioma-targeted drug delivery system based on graphene oxide. Targeted peptide chlorotoxin-conjugated graphene oxide (CTX-GO) sheets were successfully synthesized and characterized. Doxorubicin was loaded onto CTX-GO (CTX-GO/DOX) with high efficiency (570 mg doxorubicin per gram CTX-GO) via noncovalent interactions. Doxorubicin release was pH-dependent and showed sustained-release properties. Cytotoxicity experiments demonstrated that CTX-GO/DOX mediated the highest rate of death of glioma cells compared with free doxorubicin or graphene oxide loaded with doxorubicin only. Further, conjugation with chlorotoxin enhanced accumulation of doxorubicin within glioma cells. These findings indicate that CTX-GO is a promising platform for drug delivery and provide a rationale for developing a glioma-specific drug delivery system. |
format | Online Article Text |
id | pubmed-3964034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-39640342014-03-26 Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug Wang, Hao Gu, Wei Xiao, Ning Ye, Ling Xu, Qunyuan Int J Nanomedicine Original Research Current chemotherapy for glioma is rarely satisfactory due to low therapeutic efficiency and systemic side effects. We have developed a glioma-targeted drug delivery system based on graphene oxide. Targeted peptide chlorotoxin-conjugated graphene oxide (CTX-GO) sheets were successfully synthesized and characterized. Doxorubicin was loaded onto CTX-GO (CTX-GO/DOX) with high efficiency (570 mg doxorubicin per gram CTX-GO) via noncovalent interactions. Doxorubicin release was pH-dependent and showed sustained-release properties. Cytotoxicity experiments demonstrated that CTX-GO/DOX mediated the highest rate of death of glioma cells compared with free doxorubicin or graphene oxide loaded with doxorubicin only. Further, conjugation with chlorotoxin enhanced accumulation of doxorubicin within glioma cells. These findings indicate that CTX-GO is a promising platform for drug delivery and provide a rationale for developing a glioma-specific drug delivery system. Dove Medical Press 2014-03-18 /pmc/articles/PMC3964034/ /pubmed/24672236 http://dx.doi.org/10.2147/IJN.S58783 Text en © 2014 Wang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Wang, Hao Gu, Wei Xiao, Ning Ye, Ling Xu, Qunyuan Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug |
title | Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug |
title_full | Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug |
title_fullStr | Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug |
title_full_unstemmed | Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug |
title_short | Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug |
title_sort | chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964034/ https://www.ncbi.nlm.nih.gov/pubmed/24672236 http://dx.doi.org/10.2147/IJN.S58783 |
work_keys_str_mv | AT wanghao chlorotoxinconjugatedgrapheneoxidefortargeteddeliveryofananticancerdrug AT guwei chlorotoxinconjugatedgrapheneoxidefortargeteddeliveryofananticancerdrug AT xiaoning chlorotoxinconjugatedgrapheneoxidefortargeteddeliveryofananticancerdrug AT yeling chlorotoxinconjugatedgrapheneoxidefortargeteddeliveryofananticancerdrug AT xuqunyuan chlorotoxinconjugatedgrapheneoxidefortargeteddeliveryofananticancerdrug |