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Oncogene mutational profile in nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a common tumor in Southern China, but the oncogene mutational status of NPC patients has not been clarified. Using time-of-flight mass spectrometry, 238 mutation hotspots in 19 oncogenes were examined in 123 NPC patients. The relationships between mutational status...

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Autores principales: Zhang, Zi-Chen, Fu, Sha, Wang, Fang, Wang, Hai-Yun, Zeng, Yi-Xin, Shao, Jian-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964172/
https://www.ncbi.nlm.nih.gov/pubmed/24672248
http://dx.doi.org/10.2147/OTT.S58791
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author Zhang, Zi-Chen
Fu, Sha
Wang, Fang
Wang, Hai-Yun
Zeng, Yi-Xin
Shao, Jian-Yong
author_facet Zhang, Zi-Chen
Fu, Sha
Wang, Fang
Wang, Hai-Yun
Zeng, Yi-Xin
Shao, Jian-Yong
author_sort Zhang, Zi-Chen
collection PubMed
description Nasopharyngeal carcinoma (NPC) is a common tumor in Southern China, but the oncogene mutational status of NPC patients has not been clarified. Using time-of-flight mass spectrometry, 238 mutation hotspots in 19 oncogenes were examined in 123 NPC patients. The relationships between mutational status and clinical data were assessed with a χ(2) or Fisher’s exact test. Survival analysis was performed using the Kaplan–Meier method with the log-rank test. In 123 patients, 21 (17.1%) NPC tumors were positive for mutations in eight oncogenes: six patients had PIK3CA mutations (4.9%), five NRAS mutations (4.1%), four KIT mutations (3.3%), two PDGFRA mutations (1.6%), two ABL mutations (1.6%), and one with simultaneous mutations in HRAS, EGFR, and BRAF (1%). Patients with mutations were more likely to relapse or develop metastasis than those with wild-type alleles (P=0.019). No differences or correlations were found in other clinical characteristics or in patient survival. No mutations were detected in oncogenes AKT1, AKT2, CDK, ERBB2, FGFR1, FGFR3, FLT3, JAK2, KRAS, MET, and RET. These results demonstrate an association between NPC and mutations in NRAS, KIT, PIK3CA, PDGFRA, and ABL, which are associated with patient relapse and metastasis.
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spelling pubmed-39641722014-03-26 Oncogene mutational profile in nasopharyngeal carcinoma Zhang, Zi-Chen Fu, Sha Wang, Fang Wang, Hai-Yun Zeng, Yi-Xin Shao, Jian-Yong Onco Targets Ther Original Research Nasopharyngeal carcinoma (NPC) is a common tumor in Southern China, but the oncogene mutational status of NPC patients has not been clarified. Using time-of-flight mass spectrometry, 238 mutation hotspots in 19 oncogenes were examined in 123 NPC patients. The relationships between mutational status and clinical data were assessed with a χ(2) or Fisher’s exact test. Survival analysis was performed using the Kaplan–Meier method with the log-rank test. In 123 patients, 21 (17.1%) NPC tumors were positive for mutations in eight oncogenes: six patients had PIK3CA mutations (4.9%), five NRAS mutations (4.1%), four KIT mutations (3.3%), two PDGFRA mutations (1.6%), two ABL mutations (1.6%), and one with simultaneous mutations in HRAS, EGFR, and BRAF (1%). Patients with mutations were more likely to relapse or develop metastasis than those with wild-type alleles (P=0.019). No differences or correlations were found in other clinical characteristics or in patient survival. No mutations were detected in oncogenes AKT1, AKT2, CDK, ERBB2, FGFR1, FGFR3, FLT3, JAK2, KRAS, MET, and RET. These results demonstrate an association between NPC and mutations in NRAS, KIT, PIK3CA, PDGFRA, and ABL, which are associated with patient relapse and metastasis. Dove Medical Press 2014-03-20 /pmc/articles/PMC3964172/ /pubmed/24672248 http://dx.doi.org/10.2147/OTT.S58791 Text en © 2014 Zhang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Zhang, Zi-Chen
Fu, Sha
Wang, Fang
Wang, Hai-Yun
Zeng, Yi-Xin
Shao, Jian-Yong
Oncogene mutational profile in nasopharyngeal carcinoma
title Oncogene mutational profile in nasopharyngeal carcinoma
title_full Oncogene mutational profile in nasopharyngeal carcinoma
title_fullStr Oncogene mutational profile in nasopharyngeal carcinoma
title_full_unstemmed Oncogene mutational profile in nasopharyngeal carcinoma
title_short Oncogene mutational profile in nasopharyngeal carcinoma
title_sort oncogene mutational profile in nasopharyngeal carcinoma
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964172/
https://www.ncbi.nlm.nih.gov/pubmed/24672248
http://dx.doi.org/10.2147/OTT.S58791
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