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Novel PI3K and mTOR Inhibitor NVP-BEZ235 Radiosensitizes Breast Cancer Cell Lines under Normoxic and Hypoxic Conditions

In the present study, we assessed, if the novel dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235 radiosensitizes triple negative (TN) MDA-MB-231 and estrogen receptor (ER) positive MCF-7 cells to ionizing radiation under various oxygen conditions, s...

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Detalles Bibliográficos
Autores principales:	Kuger, Sebastian, Cörek, Emre, Polat, Bülent, Kämmerer, Ulrike, Flentje, Michael, Djuzenova, Cholpon S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Libertas Academica 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964191/ https://www.ncbi.nlm.nih.gov/pubmed/24678241 http://dx.doi.org/10.4137/BCBCR.S13693

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