Pharmacokinetic modeling optimizes inhibition of the ‘undruggable’ EWS-FLI1 transcription factor in Ewing Sarcoma

Transcription factors have long been deemed ‘undruggable’ targets for therapeutics. Enhanced recognition of protein biochemistry as well as the need to have more targeted approaches to treat cancer has rendered transcription factors approachable for therapeutic development. Since transcription facto...

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Detalles Bibliográficos
Autores principales: Hong, Sung-Hyeok, Youbi, Sarah. E., Hong, S. Peter, Kallakury, Bhaskar, Monroe, Phillip, Erkizan, Hayriye V, Barber-Rotenberg, Julie S., Houghton, Peter, Üren, Aykut, Toretsky, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964211/
https://www.ncbi.nlm.nih.gov/pubmed/24481407

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