Minor grove binding ligands disrupt PARP-1 activation pathways

PARP-1 is a nuclear enzyme regulating transcription, chromatin restructuring, and DNA repair. PARP-1 is activated by interaction with NAD+, DNA, and core histones. Each route of PARP-1 activation leads to somewhat different outcomes. PARP-1 interactions with core histones control PARP-1 functions du...

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Detalles Bibliográficos
Autores principales: Kirsanov, Kirill I., Kotova, Elena, Makhov, Petr, Golovine, Konstantin, Lesovaya, Ekaterina A., Kolenko, Vladimir M., Yakubovskaya, Marianna G., Tulin, Alexei V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964218/
https://www.ncbi.nlm.nih.gov/pubmed/24504413

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