Managing the Child with Severe Primary Insulin-Like Growth Factor-1 Deficiency (IGFD): IGFD Diagnosis and Management

Growth failure associated with severe primary insulin-like growth factor 1 (IGF-1) deficiency (SPIGFD), a condition defined as basal IGF-1 standard deviation score (SDS) less than or equal to −3 and height SDS less than or equal to −3 in a child with normal or elevated levels of growth hormone, can...

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Autores principales: Cohen, Jay, Blethen, Sandra, Kuntze, Joyce, Smith, Susan L., Lomax, Kathleen G., Mathew, Puthenpurackal M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Therapy in Practice
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964293/
https://www.ncbi.nlm.nih.gov/pubmed/24639006
http://dx.doi.org/10.1007/s40268-014-0039-7
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author Cohen, Jay
Blethen, Sandra
Kuntze, Joyce
Smith, Susan L.
Lomax, Kathleen G.
Mathew, Puthenpurackal M.
author_facet Cohen, Jay
Blethen, Sandra
Kuntze, Joyce
Smith, Susan L.
Lomax, Kathleen G.
Mathew, Puthenpurackal M.
author_sort Cohen, Jay
collection PubMed
description Growth failure associated with severe primary insulin-like growth factor 1 (IGF-1) deficiency (SPIGFD), a condition defined as basal IGF-1 standard deviation score (SDS) less than or equal to −3 and height SDS less than or equal to −3 in a child with normal or elevated levels of growth hormone, can be successfully treated with the recombinant human IGF-1 mecasermin. In this review, we describe the most safe and effective way to use mecasermin in the treatment of patients with SPIGFD, including how to initiate dosing, key side effects, and how to monitor treatment. Finally, mention of how to reinitiate therapy is made, given the recent drug shortage with mecasermin.
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spelling pubmed-39642932014-03-25 Managing the Child with Severe Primary Insulin-Like Growth Factor-1 Deficiency (IGFD): IGFD Diagnosis and Management Cohen, Jay Blethen, Sandra Kuntze, Joyce Smith, Susan L. Lomax, Kathleen G. Mathew, Puthenpurackal M. Drugs R D Therapy in Practice Growth failure associated with severe primary insulin-like growth factor 1 (IGF-1) deficiency (SPIGFD), a condition defined as basal IGF-1 standard deviation score (SDS) less than or equal to −3 and height SDS less than or equal to −3 in a child with normal or elevated levels of growth hormone, can be successfully treated with the recombinant human IGF-1 mecasermin. In this review, we describe the most safe and effective way to use mecasermin in the treatment of patients with SPIGFD, including how to initiate dosing, key side effects, and how to monitor treatment. Finally, mention of how to reinitiate therapy is made, given the recent drug shortage with mecasermin. Springer International Publishing 2014-03-18 2014-03 /pmc/articles/PMC3964293/ /pubmed/24639006 http://dx.doi.org/10.1007/s40268-014-0039-7 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by-nc/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Therapy in Practice
Cohen, Jay
Blethen, Sandra
Kuntze, Joyce
Smith, Susan L.
Lomax, Kathleen G.
Mathew, Puthenpurackal M.
Managing the Child with Severe Primary Insulin-Like Growth Factor-1 Deficiency (IGFD): IGFD Diagnosis and Management
title Managing the Child with Severe Primary Insulin-Like Growth Factor-1 Deficiency (IGFD): IGFD Diagnosis and Management
title_full Managing the Child with Severe Primary Insulin-Like Growth Factor-1 Deficiency (IGFD): IGFD Diagnosis and Management
title_fullStr Managing the Child with Severe Primary Insulin-Like Growth Factor-1 Deficiency (IGFD): IGFD Diagnosis and Management
title_full_unstemmed Managing the Child with Severe Primary Insulin-Like Growth Factor-1 Deficiency (IGFD): IGFD Diagnosis and Management
title_short Managing the Child with Severe Primary Insulin-Like Growth Factor-1 Deficiency (IGFD): IGFD Diagnosis and Management
title_sort managing the child with severe primary insulin-like growth factor-1 deficiency (igfd): igfd diagnosis and management
topic Therapy in Practice
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964293/
https://www.ncbi.nlm.nih.gov/pubmed/24639006
http://dx.doi.org/10.1007/s40268-014-0039-7
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