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Stability of Etoposide Solutions in Disposable Infusion Devices for Day Hospital Cancer Practices

In a context of day hospital care of cancer patients, a protocol combining etoposide and carboplatin is used in paediatrics. Disposable infusion devices can be used to improve patient quality of life and to optimize nursing time. Stability data are available for carboplatin in these devices but not...

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Autores principales: Klasen, Alison, Kessari, Romain, Mercier, Lionel, Valade, Cyril, Grill, Jacques, Desmaris, Romain, Paci, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964295/
https://www.ncbi.nlm.nih.gov/pubmed/24627337
http://dx.doi.org/10.1007/s40268-014-0037-9
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author Klasen, Alison
Kessari, Romain
Mercier, Lionel
Valade, Cyril
Grill, Jacques
Desmaris, Romain
Paci, Angelo
author_facet Klasen, Alison
Kessari, Romain
Mercier, Lionel
Valade, Cyril
Grill, Jacques
Desmaris, Romain
Paci, Angelo
author_sort Klasen, Alison
collection PubMed
description In a context of day hospital care of cancer patients, a protocol combining etoposide and carboplatin is used in paediatrics. Disposable infusion devices can be used to improve patient quality of life and to optimize nursing time. Stability data are available for carboplatin in these devices but not for etoposide. The aim of this study was to determine the stability of etoposide solutions in these devices by monitoring the changing etoposide concentration. To study the changing etoposide concentration, we investigated three different concentrations, each in two different solvents: sodium chloride (NaCl) 0.9 % and dextrose 5 %, in Intermate(®) disposable infusion devices. Quantitative analyses were performed by high-performance liquid chromatography coupled with ultraviolet (UV) detection on samples collected over a 24-h study period. The results showed that 100 mg/L etoposide solutions were stable for 24 h in NaCl 0.9 % and for 12 h in dextrose 5 %, whatever the temperature. The 400-mg/L solutions were stable for 24 h in both diluents, whatever the temperature, whereas the 600-mg/L solutions when diluted in NaCl 0.9 % and dextrose 5 % in water were stable for 8 and 6 h, respectively. We found that precipitation was the main phenomenon responsible for decreased etoposide concentrations. This study allowed us to conclude that etoposide solutions prepared in Intermate(®) infusion devices are stable for day hospital administration in paediatrics. It will also allow us to conduct a future clinical study that will focus on the medico-economic feasibility of this protocol and on the evaluation of patient and nurse satisfaction.
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spelling pubmed-39642952014-03-25 Stability of Etoposide Solutions in Disposable Infusion Devices for Day Hospital Cancer Practices Klasen, Alison Kessari, Romain Mercier, Lionel Valade, Cyril Grill, Jacques Desmaris, Romain Paci, Angelo Drugs R D Short Communication In a context of day hospital care of cancer patients, a protocol combining etoposide and carboplatin is used in paediatrics. Disposable infusion devices can be used to improve patient quality of life and to optimize nursing time. Stability data are available for carboplatin in these devices but not for etoposide. The aim of this study was to determine the stability of etoposide solutions in these devices by monitoring the changing etoposide concentration. To study the changing etoposide concentration, we investigated three different concentrations, each in two different solvents: sodium chloride (NaCl) 0.9 % and dextrose 5 %, in Intermate(®) disposable infusion devices. Quantitative analyses were performed by high-performance liquid chromatography coupled with ultraviolet (UV) detection on samples collected over a 24-h study period. The results showed that 100 mg/L etoposide solutions were stable for 24 h in NaCl 0.9 % and for 12 h in dextrose 5 %, whatever the temperature. The 400-mg/L solutions were stable for 24 h in both diluents, whatever the temperature, whereas the 600-mg/L solutions when diluted in NaCl 0.9 % and dextrose 5 % in water were stable for 8 and 6 h, respectively. We found that precipitation was the main phenomenon responsible for decreased etoposide concentrations. This study allowed us to conclude that etoposide solutions prepared in Intermate(®) infusion devices are stable for day hospital administration in paediatrics. It will also allow us to conduct a future clinical study that will focus on the medico-economic feasibility of this protocol and on the evaluation of patient and nurse satisfaction. Springer International Publishing 2014-03-14 2014-03 /pmc/articles/PMC3964295/ /pubmed/24627337 http://dx.doi.org/10.1007/s40268-014-0037-9 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by-nc/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Short Communication
Klasen, Alison
Kessari, Romain
Mercier, Lionel
Valade, Cyril
Grill, Jacques
Desmaris, Romain
Paci, Angelo
Stability of Etoposide Solutions in Disposable Infusion Devices for Day Hospital Cancer Practices
title Stability of Etoposide Solutions in Disposable Infusion Devices for Day Hospital Cancer Practices
title_full Stability of Etoposide Solutions in Disposable Infusion Devices for Day Hospital Cancer Practices
title_fullStr Stability of Etoposide Solutions in Disposable Infusion Devices for Day Hospital Cancer Practices
title_full_unstemmed Stability of Etoposide Solutions in Disposable Infusion Devices for Day Hospital Cancer Practices
title_short Stability of Etoposide Solutions in Disposable Infusion Devices for Day Hospital Cancer Practices
title_sort stability of etoposide solutions in disposable infusion devices for day hospital cancer practices
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964295/
https://www.ncbi.nlm.nih.gov/pubmed/24627337
http://dx.doi.org/10.1007/s40268-014-0037-9
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