Cargando…

Network quantification of EGFR signaling unveils potential for targeted combination therapy

The epidermal growth factor receptor (EGFR) signaling network is activated in most solid tumors, and small-molecule drugs targeting this network are increasingly available. However, often only specific combinations of inhibitors are effective. Therefore, the prediction of potent combinatorial treatm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Klinger, Bertram, Sieber, Anja, Fritsche-Guenther, Raphaela, Witzel, Franziska, Berry, Leanne, Schumacher, Dirk, Yan, Yibing, Durek, Pawel, Merchant, Mark, Schäfer, Reinhold, Sers, Christine, Blüthgen, Nils
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Molecular Biology Organization 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964313/ https://www.ncbi.nlm.nih.gov/pubmed/23752269 http://dx.doi.org/10.1038/msb.2013.29

Ejemplares similares

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis
por: Fritsche-Guenther, Raphaela, et al.
Publicado: (2016)

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling
por: Fritsche-Guenther, Raphaela, et al.
Publicado: (2011)

Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS
por: Stelniec-Klotz, Iwona, et al.
Publicado: (2012)

An immediate–late gene expression module decodes ERK signal duration
por: Uhlitz, Florian, et al.
Publicado: (2017)

An immediate–late gene expression module decodes ERK signal duration
por: Uhlitz, Florian, et al.
Publicado: (2017)

Modeling unveils sex differences of signaling networks in mouse embryonic stem cells
por: Sultana, Zeba, et al.
Publicado: (2023)

The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugs
por: Rydenfelt, Mattias, et al.
Publicado: (2019)

Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe
por: Gastl, Bastian, et al.
Publicado: (2020)

Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance
por: Dorel, Mathurin, et al.
Publicado: (2021)

How scaffolds shape MAPK signaling: what we know and opportunities for systems approaches
por: Witzel, Franziska, et al.
Publicado: (2012)

SPEED2: inferring upstream pathway activity from differential gene expression
por: Rydenfelt, Mattias, et al.
Publicado: (2020)

Comparative Network Reconstruction using mixed integer programming
por: Bosdriesz, Evert, et al.
Publicado: (2018)

Ultrasensitization: Switch-Like Regulation of Cellular Signaling by Transcriptional Induction
por: Legewie, Stefan, et al.
Publicado: (2005)

Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations
por: Fritsche-Guenther, Raphaela, et al.
Publicado: (2018)

Perturbation-response genes reveal signaling footprints in cancer gene expression
por: Schubert, Michael, et al.
Publicado: (2018)

Discovering causal signaling pathways through gene-expression patterns
por: Parikh, Jignesh R., et al.
Publicado: (2010)

Isoform-specific Ras signaling is growth factor dependent
por: Hood, Fiona E., et al.
Publicado: (2019)

Neuronal activity regulates alternative exon usage
por: Denkena, Johanna, et al.
Publicado: (2020)

Unveiling resistance mechanisms to EGFR inhibitors in cholangiocarcinoma
por: Vaquero, Javier, et al.
Publicado: (2018)

Robust network inference using response logic
por: Gross, Torsten, et al.
Publicado: (2019)

Analysis of adherent cell culture lysates with low metabolite concentrations using the Biocrates AbsoluteIDQ p400 HR kit
por: Fritsche-Guenther, Raphaela, et al.
Publicado: (2022)

Uncoupling of EGFR–RAS signaling and nuclear localization of YBX1 in colorectal cancer
por: Roßner, F, et al.
Publicado: (2016)

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium
por: Brandt, Raphael, et al.
Publicado: (2019)

Growth-inhibitory Activity and Downregulation of the Class II Tumor-suppressor Gene H-rev107 in Tumor Cell Lines and Experimental Tumors
por: Sers, Christine, et al.
Publicado: (1997)

Modified Protocol of Harvesting, Extraction, and Normalization Approaches for Gas Chromatography Mass Spectrometry-Based Metabolomics Analysis of Adherent Cells Grown Under High Fetal Calf Serum Conditions
por: Fritsche-Guenther, Raphaela, et al.
Publicado: (2019)

Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids
por: Riemer, Pamela, et al.
Publicado: (2017)

Oncogenic signaling is coupled to colorectal cancer cell differentiation state
por: Sell, Thomas, et al.
Publicado: (2023)

Progression-Dependent Altered Metabolism in Osteosarcoma Resulting in Different Nutrient Source Dependencies
por: Fritsche-Guenther, Raphaela, et al.
Publicado: (2020)

Multilevel regulation of HIF-1 signaling by TTP
por: Fähling, Michael, et al.
Publicado: (2012)

Uncertainty quantification in the radiogenomics modeling of EGFR amplification in glioblastoma
por: Hu, Leland S., et al.
Publicado: (2021)

Measuring specialization in species interaction networks
por: Blüthgen, Nico, et al.
Publicado: (2006)

A Comparison of Solvent-Based Extraction Methods to Assess the Central Carbon Metabolites in Mouse Bone and Muscle
por: Dias, Daniela B., et al.
Publicado: (2022)

Signaling output: it's all about timing and feedbacks
por: Blüthgen, Nils
Publicado: (2015)

Systematic quantification of the dynamics of newly synthesized proteins unveiling their degradation pathways in human cells
por: Tong, Ming, et al.
Publicado: (2020)

Unveiling community patterns and trophic niches of tropical and temperate ants using an integrative framework of field data, stable isotopes and fatty acids
por: Rosumek, Felix B., et al.
Publicado: (2018)

Identifying mutant-specific multi-drug combinations using comparative network reconstruction
por: Bosdriesz, Evert, et al.
Publicado: (2022)

Serum Starvation Accelerates Intracellular Metabolism in Endothelial Cells
por: Lorenz, Mario, et al.
Publicado: (2023)

Identification of Y-Box Binding Protein 1 As a Core Regulator of MEK/ERK Pathway-Dependent Gene Signatures in Colorectal Cancer Cells
por: Jürchott, Karsten, et al.
Publicado: (2010)

Proteogenomic Analysis Unveils the HLA Class I-Presented Immunopeptidome in Melanoma and EGFR-Mutant Lung Adenocarcinoma
por: Qi, Yue A., et al.
Publicado: (2021)

Early senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinoma
por: Schoetz, Ulrike, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_eph6ne6v922pktjmk6h8u19r7s