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Empirically Establishing Blood Glucose Targets to Achieve HbA(1c) Goals

OBJECTIVE: To determine the average fasting, postprandial, and bedtime self-monitored blood glucose (SMBG) concentrations associated with specified HbA(1c) levels using data from the A1c-Derived Average Glucose (ADAG) study. RESEARCH DESIGN AND METHODS: The ADAG study was a multicenter observational...

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Detalles Bibliográficos
Autores principales: Wei, Nancy, Zheng, Hui, Nathan, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964488/
https://www.ncbi.nlm.nih.gov/pubmed/24513588
http://dx.doi.org/10.2337/dc13-2173
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author Wei, Nancy
Zheng, Hui
Nathan, David M.
author_facet Wei, Nancy
Zheng, Hui
Nathan, David M.
author_sort Wei, Nancy
collection PubMed
description OBJECTIVE: To determine the average fasting, postprandial, and bedtime self-monitored blood glucose (SMBG) concentrations associated with specified HbA(1c) levels using data from the A1c-Derived Average Glucose (ADAG) study. RESEARCH DESIGN AND METHODS: The ADAG study was a multicenter observational study that used continuous glucose monitoring and SMBG testing to determine the relationship between mean average glucose and HbA(1c). We used the SMBG data from 470 of the ADAG study participants (237 with type 1 diabetes and 147 with type 2 diabetes) to determine the average fasting, premeal, 90-min postmeal, and bedtime blood glucose (BG) for predefined target HbA(1c) groups between 5.5 and 8.5% (37–69 mmol/mol). t Tests were used to compare mean BG values between type 1 and type 2 diabetes groups. RESULTS: The average fasting BG needed to achieve predefined HbA(1c) target levels of 5.5–6.49% (37–47 mmol/mol), 6.5–6.99% (48–52 mmol/mol), 7.0–7.49% (52–58 mmol/mol), 7.5–7.99% (58–64 mmol/mol), and 8.0–8.5% (64–69 mmol/mol) were 122 mg/dL with 95% CI 117–127, 142 mg/dL (135–150), 152 mg/dL (143–162), 167 mg/dL (157–177), and 178 mg/dL (164–192), respectively. Postmeal BG to achieve the HbA(1c) level of 6.5–6.99% (48–52 mmol/mol) and 7.0–7.49% (52–58 mmol/mol) were 139 mg/dL (134–144) and 152 mg/dL (147–157), respectively. Bedtime BG was 153 mg/dL (145–161) and 177 mg/dL (166–188), respectively. CONCLUSIONS: We have determined the average BG at premeal, postmeal, and bedtime to achieve a variety of HbA(1c) targets. These results, based on empirical data, will help patients and providers set realistic day-to-day SMBG targets to achieve individualized HbA(1c) goals.
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spelling pubmed-39644882015-04-01 Empirically Establishing Blood Glucose Targets to Achieve HbA(1c) Goals Wei, Nancy Zheng, Hui Nathan, David M. Diabetes Care Epidemiology/Health Services Research OBJECTIVE: To determine the average fasting, postprandial, and bedtime self-monitored blood glucose (SMBG) concentrations associated with specified HbA(1c) levels using data from the A1c-Derived Average Glucose (ADAG) study. RESEARCH DESIGN AND METHODS: The ADAG study was a multicenter observational study that used continuous glucose monitoring and SMBG testing to determine the relationship between mean average glucose and HbA(1c). We used the SMBG data from 470 of the ADAG study participants (237 with type 1 diabetes and 147 with type 2 diabetes) to determine the average fasting, premeal, 90-min postmeal, and bedtime blood glucose (BG) for predefined target HbA(1c) groups between 5.5 and 8.5% (37–69 mmol/mol). t Tests were used to compare mean BG values between type 1 and type 2 diabetes groups. RESULTS: The average fasting BG needed to achieve predefined HbA(1c) target levels of 5.5–6.49% (37–47 mmol/mol), 6.5–6.99% (48–52 mmol/mol), 7.0–7.49% (52–58 mmol/mol), 7.5–7.99% (58–64 mmol/mol), and 8.0–8.5% (64–69 mmol/mol) were 122 mg/dL with 95% CI 117–127, 142 mg/dL (135–150), 152 mg/dL (143–162), 167 mg/dL (157–177), and 178 mg/dL (164–192), respectively. Postmeal BG to achieve the HbA(1c) level of 6.5–6.99% (48–52 mmol/mol) and 7.0–7.49% (52–58 mmol/mol) were 139 mg/dL (134–144) and 152 mg/dL (147–157), respectively. Bedtime BG was 153 mg/dL (145–161) and 177 mg/dL (166–188), respectively. CONCLUSIONS: We have determined the average BG at premeal, postmeal, and bedtime to achieve a variety of HbA(1c) targets. These results, based on empirical data, will help patients and providers set realistic day-to-day SMBG targets to achieve individualized HbA(1c) goals. American Diabetes Association 2014-04 2014-03-08 /pmc/articles/PMC3964488/ /pubmed/24513588 http://dx.doi.org/10.2337/dc13-2173 Text en © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Epidemiology/Health Services Research
Wei, Nancy
Zheng, Hui
Nathan, David M.
Empirically Establishing Blood Glucose Targets to Achieve HbA(1c) Goals
title Empirically Establishing Blood Glucose Targets to Achieve HbA(1c) Goals
title_full Empirically Establishing Blood Glucose Targets to Achieve HbA(1c) Goals
title_fullStr Empirically Establishing Blood Glucose Targets to Achieve HbA(1c) Goals
title_full_unstemmed Empirically Establishing Blood Glucose Targets to Achieve HbA(1c) Goals
title_short Empirically Establishing Blood Glucose Targets to Achieve HbA(1c) Goals
title_sort empirically establishing blood glucose targets to achieve hba(1c) goals
topic Epidemiology/Health Services Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964488/
https://www.ncbi.nlm.nih.gov/pubmed/24513588
http://dx.doi.org/10.2337/dc13-2173
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