Cargando…

Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice

Recently topical use of 2% Ketoconazole solution has been reported to have a therapeutic effect on androgenic alopecia. Minoxidil is a vasodilatory medication used primarily as antihypertensive drug. It was discovered to have the side effect of hair growth and reversing baldness. Tretinoin is common...

Descripción completa

Detalles Bibliográficos
Autores principales: Aldhalimi, Muhsin A., Hadi, Najah R., Ghafil, Fadaa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964684/
https://www.ncbi.nlm.nih.gov/pubmed/24734193
http://dx.doi.org/10.1155/2014/575423
_version_ 1782479221193441280
author Aldhalimi, Muhsin A.
Hadi, Najah R.
Ghafil, Fadaa A.
author_facet Aldhalimi, Muhsin A.
Hadi, Najah R.
Ghafil, Fadaa A.
author_sort Aldhalimi, Muhsin A.
collection PubMed
description Recently topical use of 2% Ketoconazole solution has been reported to have a therapeutic effect on androgenic alopecia. Minoxidil is a vasodilatory medication used primarily as antihypertensive drug. It was discovered to have the side effect of hair growth and reversing baldness. Tretinoin is commonly used topically for acne treatment and in the treatment of photoaging. It is used by some as hair loss treatment. Objective. To compare the stimulatory effect of Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on hair growth in a mouse model. Materials and Methods. Coat hairs on the dorsal skin of seven weeks old male mice were gently clipped and then stained by using commercial dye. These mice were divided into four groups each of five treated with topical application of ethanol 95%, Ketoconazole solution 2%, Minoxidil solution 5%, and Minoxidil with Tretinoin solution 0.1%, respectively. The drugs were applied once daily for three weeks, the clipped area was photographed, and the ratio of regrown coat area was calculated. Results. The results demonstrated that Ketoconazole, Minoxidil, and Minoxidil with Tretinoin had a significant stimulatory effect on hair growth compared with the control group and Minoxidil was the most effective drug among them.
format Online
Article
Text
id pubmed-3964684
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-39646842014-04-14 Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice Aldhalimi, Muhsin A. Hadi, Najah R. Ghafil, Fadaa A. ISRN Pharmacol Research Article Recently topical use of 2% Ketoconazole solution has been reported to have a therapeutic effect on androgenic alopecia. Minoxidil is a vasodilatory medication used primarily as antihypertensive drug. It was discovered to have the side effect of hair growth and reversing baldness. Tretinoin is commonly used topically for acne treatment and in the treatment of photoaging. It is used by some as hair loss treatment. Objective. To compare the stimulatory effect of Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on hair growth in a mouse model. Materials and Methods. Coat hairs on the dorsal skin of seven weeks old male mice were gently clipped and then stained by using commercial dye. These mice were divided into four groups each of five treated with topical application of ethanol 95%, Ketoconazole solution 2%, Minoxidil solution 5%, and Minoxidil with Tretinoin solution 0.1%, respectively. The drugs were applied once daily for three weeks, the clipped area was photographed, and the ratio of regrown coat area was calculated. Results. The results demonstrated that Ketoconazole, Minoxidil, and Minoxidil with Tretinoin had a significant stimulatory effect on hair growth compared with the control group and Minoxidil was the most effective drug among them. Hindawi Publishing Corporation 2014-03-09 /pmc/articles/PMC3964684/ /pubmed/24734193 http://dx.doi.org/10.1155/2014/575423 Text en Copyright © 2014 Muhsin A. Aldhalimi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Aldhalimi, Muhsin A.
Hadi, Najah R.
Ghafil, Fadaa A.
Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice
title Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice
title_full Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice
title_fullStr Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice
title_full_unstemmed Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice
title_short Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice
title_sort promotive effect of topical ketoconazole, minoxidil, and minoxidil with tretinoin on hair growth in male mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964684/
https://www.ncbi.nlm.nih.gov/pubmed/24734193
http://dx.doi.org/10.1155/2014/575423
work_keys_str_mv AT aldhalimimuhsina promotiveeffectoftopicalketoconazoleminoxidilandminoxidilwithtretinoinonhairgrowthinmalemice
AT hadinajahr promotiveeffectoftopicalketoconazoleminoxidilandminoxidilwithtretinoinonhairgrowthinmalemice
AT ghafilfadaaa promotiveeffectoftopicalketoconazoleminoxidilandminoxidilwithtretinoinonhairgrowthinmalemice