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Estrogen Deficiency and the Origin of Obesity during Menopause

Sex hormones strongly influence body fat distribution and adipocyte differentiation. Estrogens and testosterone differentially affect adipocyte physiology, but the importance of estrogens in the development of metabolic diseases during menopause is disputed. Estrogens and estrogen receptors regulate...

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Autores principales: Lizcano, Fernando, Guzmán, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964739/
https://www.ncbi.nlm.nih.gov/pubmed/24734243
http://dx.doi.org/10.1155/2014/757461
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author Lizcano, Fernando
Guzmán, Guillermo
author_facet Lizcano, Fernando
Guzmán, Guillermo
author_sort Lizcano, Fernando
collection PubMed
description Sex hormones strongly influence body fat distribution and adipocyte differentiation. Estrogens and testosterone differentially affect adipocyte physiology, but the importance of estrogens in the development of metabolic diseases during menopause is disputed. Estrogens and estrogen receptors regulate various aspects of glucose and lipid metabolism. Disturbances of this metabolic signal lead to the development of metabolic syndrome and a higher cardiovascular risk in women. The absence of estrogens is a clue factor in the onset of cardiovascular disease during the menopausal period, which is characterized by lipid profile variations and predominant abdominal fat accumulation. However, influence of the absence of these hormones and its relationship to higher obesity in women during menopause are not clear. This systematic review discusses of the role of estrogens and estrogen receptors in adipocyte differentiation, and its control by the central nervous systemn and the possible role of estrogen-like compounds and endocrine disruptors chemicals are discussed. Finally, the interaction between the decrease in estrogen secretion and the prevalence of obesity in menopausal women is examined. We will consider if the absence of estrogens have a significant effect of obesity in menopausal women.
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spelling pubmed-39647392014-04-14 Estrogen Deficiency and the Origin of Obesity during Menopause Lizcano, Fernando Guzmán, Guillermo Biomed Res Int Review Article Sex hormones strongly influence body fat distribution and adipocyte differentiation. Estrogens and testosterone differentially affect adipocyte physiology, but the importance of estrogens in the development of metabolic diseases during menopause is disputed. Estrogens and estrogen receptors regulate various aspects of glucose and lipid metabolism. Disturbances of this metabolic signal lead to the development of metabolic syndrome and a higher cardiovascular risk in women. The absence of estrogens is a clue factor in the onset of cardiovascular disease during the menopausal period, which is characterized by lipid profile variations and predominant abdominal fat accumulation. However, influence of the absence of these hormones and its relationship to higher obesity in women during menopause are not clear. This systematic review discusses of the role of estrogens and estrogen receptors in adipocyte differentiation, and its control by the central nervous systemn and the possible role of estrogen-like compounds and endocrine disruptors chemicals are discussed. Finally, the interaction between the decrease in estrogen secretion and the prevalence of obesity in menopausal women is examined. We will consider if the absence of estrogens have a significant effect of obesity in menopausal women. Hindawi Publishing Corporation 2014 2014-03-06 /pmc/articles/PMC3964739/ /pubmed/24734243 http://dx.doi.org/10.1155/2014/757461 Text en Copyright © 2014 F. Lizcano and G. Guzmán. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lizcano, Fernando
Guzmán, Guillermo
Estrogen Deficiency and the Origin of Obesity during Menopause
title Estrogen Deficiency and the Origin of Obesity during Menopause
title_full Estrogen Deficiency and the Origin of Obesity during Menopause
title_fullStr Estrogen Deficiency and the Origin of Obesity during Menopause
title_full_unstemmed Estrogen Deficiency and the Origin of Obesity during Menopause
title_short Estrogen Deficiency and the Origin of Obesity during Menopause
title_sort estrogen deficiency and the origin of obesity during menopause
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964739/
https://www.ncbi.nlm.nih.gov/pubmed/24734243
http://dx.doi.org/10.1155/2014/757461
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