Total Synthesis of the Antitumor Antibiotic (±)-Streptonigrin: First- and Second-Generation Routes for de Novo Pyridine Formation Using Ring-Closing Metathesis

[Image: see text] The total synthesis of (±)-streptonigrin, a potent tetracyclic aminoquinoline-5,8-dione antitumor antibiotic that reached phase II clinical trials in the 1970s, is described. Two routes to construct a key pentasubstituted pyridine fragment are depicted, both relying on ring-closing...

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Detalles Bibliográficos
Autores principales: Donohoe, Timothy J., Jones, Christopher R., Kornahrens, Anne F., Barbosa, Luiz C. A., Walport, Louise J., Tatton, Matthew R., O’Hagan, Michael, Rathi, Akshat H., Baker, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964827/
https://www.ncbi.nlm.nih.gov/pubmed/24328139
http://dx.doi.org/10.1021/jo402388f

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