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Oral Tongue Squamous Cell Carcinoma in Young Women: A Matched Comparison—Do Outcomes Justify Treatment Intensity?

Background. The incidence of oral tongue squamous cell carcinoma (OTSCC) in young women is increasing with uncertain outcomes compared to traditional patients. Published outcomes data are at odds in this cohort of young women. Methods. Retrospective analysis comparing demographic, clinicopathologic,...

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Detalles Bibliográficos
Autores principales: Goepfert, Ryan P., Kezirian, Eric J., Wang, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964833/
https://www.ncbi.nlm.nih.gov/pubmed/24734200
http://dx.doi.org/10.1155/2014/529395
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author Goepfert, Ryan P.
Kezirian, Eric J.
Wang, Steven J.
author_facet Goepfert, Ryan P.
Kezirian, Eric J.
Wang, Steven J.
author_sort Goepfert, Ryan P.
collection PubMed
description Background. The incidence of oral tongue squamous cell carcinoma (OTSCC) in young women is increasing with uncertain outcomes compared to traditional patients. Published outcomes data are at odds in this cohort of young women. Methods. Retrospective analysis comparing demographic, clinicopathologic, and outcomes data of women OTSCC patients younger than 45 years old matched 1 : 2 by stage with men both younger and older than 45 and women older than 45. Results. No disease-free or overall survival differences were found between cohorts. Young women were significantly more likely to receive radiation therapy, particularly in stage I disease, even when controlling for common pathologic indications. Conclusions. OTSCC in young women was not associated with worse outcomes compared to a matched cohort of other patients. Increased frequency of radiation treatment for this cohort may not be justified.
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spelling pubmed-39648332014-04-14 Oral Tongue Squamous Cell Carcinoma in Young Women: A Matched Comparison—Do Outcomes Justify Treatment Intensity? Goepfert, Ryan P. Kezirian, Eric J. Wang, Steven J. ISRN Otolaryngol Research Article Background. The incidence of oral tongue squamous cell carcinoma (OTSCC) in young women is increasing with uncertain outcomes compared to traditional patients. Published outcomes data are at odds in this cohort of young women. Methods. Retrospective analysis comparing demographic, clinicopathologic, and outcomes data of women OTSCC patients younger than 45 years old matched 1 : 2 by stage with men both younger and older than 45 and women older than 45. Results. No disease-free or overall survival differences were found between cohorts. Young women were significantly more likely to receive radiation therapy, particularly in stage I disease, even when controlling for common pathologic indications. Conclusions. OTSCC in young women was not associated with worse outcomes compared to a matched cohort of other patients. Increased frequency of radiation treatment for this cohort may not be justified. Hindawi Publishing Corporation 2014-03-10 /pmc/articles/PMC3964833/ /pubmed/24734200 http://dx.doi.org/10.1155/2014/529395 Text en Copyright © 2014 Ryan P. Goepfert et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Goepfert, Ryan P.
Kezirian, Eric J.
Wang, Steven J.
Oral Tongue Squamous Cell Carcinoma in Young Women: A Matched Comparison—Do Outcomes Justify Treatment Intensity?
title Oral Tongue Squamous Cell Carcinoma in Young Women: A Matched Comparison—Do Outcomes Justify Treatment Intensity?
title_full Oral Tongue Squamous Cell Carcinoma in Young Women: A Matched Comparison—Do Outcomes Justify Treatment Intensity?
title_fullStr Oral Tongue Squamous Cell Carcinoma in Young Women: A Matched Comparison—Do Outcomes Justify Treatment Intensity?
title_full_unstemmed Oral Tongue Squamous Cell Carcinoma in Young Women: A Matched Comparison—Do Outcomes Justify Treatment Intensity?
title_short Oral Tongue Squamous Cell Carcinoma in Young Women: A Matched Comparison—Do Outcomes Justify Treatment Intensity?
title_sort oral tongue squamous cell carcinoma in young women: a matched comparison—do outcomes justify treatment intensity?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964833/
https://www.ncbi.nlm.nih.gov/pubmed/24734200
http://dx.doi.org/10.1155/2014/529395
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