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Effects of three blood purification methods on serum fibroblast growth factor-23 clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis

The aim of the present study was to investigate the effects of three blood purification methods on fibroblast growth factor-23 (FGF-23) clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis (MHD). In addition, the correlation between serum FGF-23 and phosphorus (Pi) levels...

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Autores principales: MIAO, LI-YING, ZHU, BIN, HE, XIAO-ZHOU, LIU, JIN-FENG, JIN, LI-NA, LI, XIU-RONG, XUE, LI-NA, HUANG, TIAN, SHEN, JIAN-QIN, XING, CHANG-YING
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964936/
https://www.ncbi.nlm.nih.gov/pubmed/24669256
http://dx.doi.org/10.3892/etm.2014.1543
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author MIAO, LI-YING
ZHU, BIN
HE, XIAO-ZHOU
LIU, JIN-FENG
JIN, LI-NA
LI, XIU-RONG
XUE, LI-NA
HUANG, TIAN
SHEN, JIAN-QIN
XING, CHANG-YING
author_facet MIAO, LI-YING
ZHU, BIN
HE, XIAO-ZHOU
LIU, JIN-FENG
JIN, LI-NA
LI, XIU-RONG
XUE, LI-NA
HUANG, TIAN
SHEN, JIAN-QIN
XING, CHANG-YING
author_sort MIAO, LI-YING
collection PubMed
description The aim of the present study was to investigate the effects of three blood purification methods on fibroblast growth factor-23 (FGF-23) clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis (MHD). In addition, the correlation between serum FGF-23 and phosphorus (Pi) levels and the clinical implications were identified. Sixty-five MHD patients with hyperphosphatemia were randomly divided into three groups: Hemodialysis, HD (n=23); hemodiafiltration, HDF (n=21); and hemodialysis+hemoperfusion, HD+HP (n=21) groups. Serum Pi, FGF-23, blood urea nitrogen, serum creatinine and associated bio-marker levels were measured prior to and following treatment. The expression level of serum FGF-23 was observed to be positively correlated with Pi (r=0.45, P<0.01). The three blood purification methods that were adopted for the present study exhibited significant and effective clearance of serum Pi (P<0.05). The post-treatment serum FGF-23 levels were significantly decreased in the HDF and HD+HP groups (P<0.05). Therefore, HDF may be an effective method for clearing serum FGF-23 in MHD patients exhibiting hyperphosphatemia.
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spelling pubmed-39649362014-03-25 Effects of three blood purification methods on serum fibroblast growth factor-23 clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis MIAO, LI-YING ZHU, BIN HE, XIAO-ZHOU LIU, JIN-FENG JIN, LI-NA LI, XIU-RONG XUE, LI-NA HUANG, TIAN SHEN, JIAN-QIN XING, CHANG-YING Exp Ther Med Articles The aim of the present study was to investigate the effects of three blood purification methods on fibroblast growth factor-23 (FGF-23) clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis (MHD). In addition, the correlation between serum FGF-23 and phosphorus (Pi) levels and the clinical implications were identified. Sixty-five MHD patients with hyperphosphatemia were randomly divided into three groups: Hemodialysis, HD (n=23); hemodiafiltration, HDF (n=21); and hemodialysis+hemoperfusion, HD+HP (n=21) groups. Serum Pi, FGF-23, blood urea nitrogen, serum creatinine and associated bio-marker levels were measured prior to and following treatment. The expression level of serum FGF-23 was observed to be positively correlated with Pi (r=0.45, P<0.01). The three blood purification methods that were adopted for the present study exhibited significant and effective clearance of serum Pi (P<0.05). The post-treatment serum FGF-23 levels were significantly decreased in the HDF and HD+HP groups (P<0.05). Therefore, HDF may be an effective method for clearing serum FGF-23 in MHD patients exhibiting hyperphosphatemia. D.A. Spandidos 2014-04 2014-02-13 /pmc/articles/PMC3964936/ /pubmed/24669256 http://dx.doi.org/10.3892/etm.2014.1543 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
MIAO, LI-YING
ZHU, BIN
HE, XIAO-ZHOU
LIU, JIN-FENG
JIN, LI-NA
LI, XIU-RONG
XUE, LI-NA
HUANG, TIAN
SHEN, JIAN-QIN
XING, CHANG-YING
Effects of three blood purification methods on serum fibroblast growth factor-23 clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis
title Effects of three blood purification methods on serum fibroblast growth factor-23 clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis
title_full Effects of three blood purification methods on serum fibroblast growth factor-23 clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis
title_fullStr Effects of three blood purification methods on serum fibroblast growth factor-23 clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis
title_full_unstemmed Effects of three blood purification methods on serum fibroblast growth factor-23 clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis
title_short Effects of three blood purification methods on serum fibroblast growth factor-23 clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis
title_sort effects of three blood purification methods on serum fibroblast growth factor-23 clearance in patients with hyperphosphatemia undergoing maintenance hemodialysis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964936/
https://www.ncbi.nlm.nih.gov/pubmed/24669256
http://dx.doi.org/10.3892/etm.2014.1543
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