Cargando…
canSAR: updated cancer research and drug discovery knowledgebase
canSAR (http://cansar.icr.ac.uk) is a public integrative cancer-focused knowledgebase for the support of cancer translational research and drug discovery. Through the integration of biological, pharmacological, chemical, structural biology and protein network data, it provides a single information p...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964944/ https://www.ncbi.nlm.nih.gov/pubmed/24304894 http://dx.doi.org/10.1093/nar/gkt1182 |
_version_ | 1782479263520260096 |
---|---|
author | Bulusu, Krishna C. Tym, Joseph E. Coker, Elizabeth A. Schierz, Amanda C. Al-Lazikani, Bissan |
author_facet | Bulusu, Krishna C. Tym, Joseph E. Coker, Elizabeth A. Schierz, Amanda C. Al-Lazikani, Bissan |
author_sort | Bulusu, Krishna C. |
collection | PubMed |
description | canSAR (http://cansar.icr.ac.uk) is a public integrative cancer-focused knowledgebase for the support of cancer translational research and drug discovery. Through the integration of biological, pharmacological, chemical, structural biology and protein network data, it provides a single information portal to answer complex multidisciplinary questions including—among many others—what is known about a protein, in which cancers is it expressed or mutated, and what chemical tools and cell line models can be used to experimentally probe its activity? What is known about a drug, its cellular sensitivity profile and what proteins is it known to bind that may explain unusual bioactivity? Here we describe major enhancements to canSAR including new data, improved search and browsing capabilities and new target, cancer cell line, protein family and 3D structure summaries and tools. |
format | Online Article Text |
id | pubmed-3964944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-39649442014-03-25 canSAR: updated cancer research and drug discovery knowledgebase Bulusu, Krishna C. Tym, Joseph E. Coker, Elizabeth A. Schierz, Amanda C. Al-Lazikani, Bissan Nucleic Acids Res VI. Genomic variation, diseases and drugs canSAR (http://cansar.icr.ac.uk) is a public integrative cancer-focused knowledgebase for the support of cancer translational research and drug discovery. Through the integration of biological, pharmacological, chemical, structural biology and protein network data, it provides a single information portal to answer complex multidisciplinary questions including—among many others—what is known about a protein, in which cancers is it expressed or mutated, and what chemical tools and cell line models can be used to experimentally probe its activity? What is known about a drug, its cellular sensitivity profile and what proteins is it known to bind that may explain unusual bioactivity? Here we describe major enhancements to canSAR including new data, improved search and browsing capabilities and new target, cancer cell line, protein family and 3D structure summaries and tools. Oxford University Press 2014-01-01 2013-12-03 /pmc/articles/PMC3964944/ /pubmed/24304894 http://dx.doi.org/10.1093/nar/gkt1182 Text en © The Author(s) 2013. Published by Oxford University Press. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | VI. Genomic variation, diseases and drugs Bulusu, Krishna C. Tym, Joseph E. Coker, Elizabeth A. Schierz, Amanda C. Al-Lazikani, Bissan canSAR: updated cancer research and drug discovery knowledgebase |
title | canSAR: updated cancer research and drug discovery knowledgebase |
title_full | canSAR: updated cancer research and drug discovery knowledgebase |
title_fullStr | canSAR: updated cancer research and drug discovery knowledgebase |
title_full_unstemmed | canSAR: updated cancer research and drug discovery knowledgebase |
title_short | canSAR: updated cancer research and drug discovery knowledgebase |
title_sort | cansar: updated cancer research and drug discovery knowledgebase |
topic | VI. Genomic variation, diseases and drugs |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964944/ https://www.ncbi.nlm.nih.gov/pubmed/24304894 http://dx.doi.org/10.1093/nar/gkt1182 |
work_keys_str_mv | AT bulusukrishnac cansarupdatedcancerresearchanddrugdiscoveryknowledgebase AT tymjosephe cansarupdatedcancerresearchanddrugdiscoveryknowledgebase AT cokerelizabetha cansarupdatedcancerresearchanddrugdiscoveryknowledgebase AT schierzamandac cansarupdatedcancerresearchanddrugdiscoveryknowledgebase AT allazikanibissan cansarupdatedcancerresearchanddrugdiscoveryknowledgebase |