Cargando…

miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions

MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target in...

Descripción completa

Detalles Bibliográficos
Autores principales: Hsu, Sheng-Da, Tseng, Yu-Ting, Shrestha, Sirjana, Lin, Yu-Ling, Khaleel, Anas, Chou, Chih-Hung, Chu, Chao-Fang, Huang, Hsi-Yuan, Lin, Ching-Min, Ho, Shu-Yi, Jian, Ting-Yan, Lin, Feng-Mao, Chang, Tzu-Hao, Weng, Shun-Long, Liao, Kuang-Wen, Liao, I-En, Liu, Chun-Chi, Huang, Hsien-Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965058/
https://www.ncbi.nlm.nih.gov/pubmed/24304892
http://dx.doi.org/10.1093/nar/gkt1266
_version_ 1782479289183109120
author Hsu, Sheng-Da
Tseng, Yu-Ting
Shrestha, Sirjana
Lin, Yu-Ling
Khaleel, Anas
Chou, Chih-Hung
Chu, Chao-Fang
Huang, Hsi-Yuan
Lin, Ching-Min
Ho, Shu-Yi
Jian, Ting-Yan
Lin, Feng-Mao
Chang, Tzu-Hao
Weng, Shun-Long
Liao, Kuang-Wen
Liao, I-En
Liu, Chun-Chi
Huang, Hsien-Da
author_facet Hsu, Sheng-Da
Tseng, Yu-Ting
Shrestha, Sirjana
Lin, Yu-Ling
Khaleel, Anas
Chou, Chih-Hung
Chu, Chao-Fang
Huang, Hsi-Yuan
Lin, Ching-Min
Ho, Shu-Yi
Jian, Ting-Yan
Lin, Feng-Mao
Chang, Tzu-Hao
Weng, Shun-Long
Liao, Kuang-Wen
Liao, I-En
Liu, Chun-Chi
Huang, Hsien-Da
author_sort Hsu, Sheng-Da
collection PubMed
description MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.
format Online
Article
Text
id pubmed-3965058
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-39650582014-03-25 miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions Hsu, Sheng-Da Tseng, Yu-Ting Shrestha, Sirjana Lin, Yu-Ling Khaleel, Anas Chou, Chih-Hung Chu, Chao-Fang Huang, Hsi-Yuan Lin, Ching-Min Ho, Shu-Yi Jian, Ting-Yan Lin, Feng-Mao Chang, Tzu-Hao Weng, Shun-Long Liao, Kuang-Wen Liao, I-En Liu, Chun-Chi Huang, Hsien-Da Nucleic Acids Res I. Nucleic acid sequence, structure and regulation MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system. Oxford University Press 2014-01-01 2013-12-04 /pmc/articles/PMC3965058/ /pubmed/24304892 http://dx.doi.org/10.1093/nar/gkt1266 Text en © The Author(s) 2013. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle I. Nucleic acid sequence, structure and regulation
Hsu, Sheng-Da
Tseng, Yu-Ting
Shrestha, Sirjana
Lin, Yu-Ling
Khaleel, Anas
Chou, Chih-Hung
Chu, Chao-Fang
Huang, Hsi-Yuan
Lin, Ching-Min
Ho, Shu-Yi
Jian, Ting-Yan
Lin, Feng-Mao
Chang, Tzu-Hao
Weng, Shun-Long
Liao, Kuang-Wen
Liao, I-En
Liu, Chun-Chi
Huang, Hsien-Da
miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions
title miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions
title_full miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions
title_fullStr miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions
title_full_unstemmed miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions
title_short miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions
title_sort mirtarbase update 2014: an information resource for experimentally validated mirna-target interactions
topic I. Nucleic acid sequence, structure and regulation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965058/
https://www.ncbi.nlm.nih.gov/pubmed/24304892
http://dx.doi.org/10.1093/nar/gkt1266
work_keys_str_mv AT hsushengda mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT tsengyuting mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT shresthasirjana mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT linyuling mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT khaleelanas mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT chouchihhung mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT chuchaofang mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT huanghsiyuan mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT linchingmin mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT hoshuyi mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT jiantingyan mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT linfengmao mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT changtzuhao mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT wengshunlong mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT liaokuangwen mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT liaoien mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT liuchunchi mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions
AT huanghsienda mirtarbaseupdate2014aninformationresourceforexperimentallyvalidatedmirnatargetinteractions