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miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions
MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target in...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965058/ https://www.ncbi.nlm.nih.gov/pubmed/24304892 http://dx.doi.org/10.1093/nar/gkt1266 |
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author | Hsu, Sheng-Da Tseng, Yu-Ting Shrestha, Sirjana Lin, Yu-Ling Khaleel, Anas Chou, Chih-Hung Chu, Chao-Fang Huang, Hsi-Yuan Lin, Ching-Min Ho, Shu-Yi Jian, Ting-Yan Lin, Feng-Mao Chang, Tzu-Hao Weng, Shun-Long Liao, Kuang-Wen Liao, I-En Liu, Chun-Chi Huang, Hsien-Da |
author_facet | Hsu, Sheng-Da Tseng, Yu-Ting Shrestha, Sirjana Lin, Yu-Ling Khaleel, Anas Chou, Chih-Hung Chu, Chao-Fang Huang, Hsi-Yuan Lin, Ching-Min Ho, Shu-Yi Jian, Ting-Yan Lin, Feng-Mao Chang, Tzu-Hao Weng, Shun-Long Liao, Kuang-Wen Liao, I-En Liu, Chun-Chi Huang, Hsien-Da |
author_sort | Hsu, Sheng-Da |
collection | PubMed |
description | MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system. |
format | Online Article Text |
id | pubmed-3965058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-39650582014-03-25 miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions Hsu, Sheng-Da Tseng, Yu-Ting Shrestha, Sirjana Lin, Yu-Ling Khaleel, Anas Chou, Chih-Hung Chu, Chao-Fang Huang, Hsi-Yuan Lin, Ching-Min Ho, Shu-Yi Jian, Ting-Yan Lin, Feng-Mao Chang, Tzu-Hao Weng, Shun-Long Liao, Kuang-Wen Liao, I-En Liu, Chun-Chi Huang, Hsien-Da Nucleic Acids Res I. Nucleic acid sequence, structure and regulation MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system. Oxford University Press 2014-01-01 2013-12-04 /pmc/articles/PMC3965058/ /pubmed/24304892 http://dx.doi.org/10.1093/nar/gkt1266 Text en © The Author(s) 2013. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | I. Nucleic acid sequence, structure and regulation Hsu, Sheng-Da Tseng, Yu-Ting Shrestha, Sirjana Lin, Yu-Ling Khaleel, Anas Chou, Chih-Hung Chu, Chao-Fang Huang, Hsi-Yuan Lin, Ching-Min Ho, Shu-Yi Jian, Ting-Yan Lin, Feng-Mao Chang, Tzu-Hao Weng, Shun-Long Liao, Kuang-Wen Liao, I-En Liu, Chun-Chi Huang, Hsien-Da miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions |
title | miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions |
title_full | miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions |
title_fullStr | miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions |
title_full_unstemmed | miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions |
title_short | miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions |
title_sort | mirtarbase update 2014: an information resource for experimentally validated mirna-target interactions |
topic | I. Nucleic acid sequence, structure and regulation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965058/ https://www.ncbi.nlm.nih.gov/pubmed/24304892 http://dx.doi.org/10.1093/nar/gkt1266 |
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