The ChEMBL bioactivity database: an update

ChEMBL is an open large-scale bioactivity database (https://www.ebi.ac.uk/chembl), previously described in the 2012 Nucleic Acids Research Database Issue. Since then, a variety of new data sources and improvements in functionality have contributed to the growth and utility of the resource. In partic...

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Autores principales: Bento, A. Patrícia, Gaulton, Anna, Hersey, Anne, Bellis, Louisa J., Chambers, Jon, Davies, Mark, Krüger, Felix A., Light, Yvonne, Mak, Lora, McGlinchey, Shaun, Nowotka, Michal, Papadatos, George, Santos, Rita, Overington, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
VI. Genomic variation, diseases and drugs
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965067/
https://www.ncbi.nlm.nih.gov/pubmed/24214965
http://dx.doi.org/10.1093/nar/gkt1031
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author Bento, A. Patrícia
Gaulton, Anna
Hersey, Anne
Bellis, Louisa J.
Chambers, Jon
Davies, Mark
Krüger, Felix A.
Light, Yvonne
Mak, Lora
McGlinchey, Shaun
Nowotka, Michal
Papadatos, George
Santos, Rita
Overington, John P.
author_facet Bento, A. Patrícia
Gaulton, Anna
Hersey, Anne
Bellis, Louisa J.
Chambers, Jon
Davies, Mark
Krüger, Felix A.
Light, Yvonne
Mak, Lora
McGlinchey, Shaun
Nowotka, Michal
Papadatos, George
Santos, Rita
Overington, John P.
author_sort Bento, A. Patrícia
collection PubMed
description ChEMBL is an open large-scale bioactivity database (https://www.ebi.ac.uk/chembl), previously described in the 2012 Nucleic Acids Research Database Issue. Since then, a variety of new data sources and improvements in functionality have contributed to the growth and utility of the resource. In particular, more comprehensive tracking of compounds from research stages through clinical development to market is provided through the inclusion of data from United States Adopted Name applications; a new richer data model for representing drug targets has been developed; and a number of methods have been put in place to allow users to more easily identify reliable data. Finally, access to ChEMBL is now available via a new Resource Description Framework format, in addition to the web-based interface, data downloads and web services.
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spelling pubmed-39650672014-03-25 The ChEMBL bioactivity database: an update Bento, A. Patrícia Gaulton, Anna Hersey, Anne Bellis, Louisa J. Chambers, Jon Davies, Mark Krüger, Felix A. Light, Yvonne Mak, Lora McGlinchey, Shaun Nowotka, Michal Papadatos, George Santos, Rita Overington, John P. Nucleic Acids Res VI. Genomic variation, diseases and drugs ChEMBL is an open large-scale bioactivity database (https://www.ebi.ac.uk/chembl), previously described in the 2012 Nucleic Acids Research Database Issue. Since then, a variety of new data sources and improvements in functionality have contributed to the growth and utility of the resource. In particular, more comprehensive tracking of compounds from research stages through clinical development to market is provided through the inclusion of data from United States Adopted Name applications; a new richer data model for representing drug targets has been developed; and a number of methods have been put in place to allow users to more easily identify reliable data. Finally, access to ChEMBL is now available via a new Resource Description Framework format, in addition to the web-based interface, data downloads and web services. Oxford University Press 2014-01-01 2013-11-07 /pmc/articles/PMC3965067/ /pubmed/24214965 http://dx.doi.org/10.1093/nar/gkt1031 Text en © The Author(s) 2013. Published by Oxford University Press. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle VI. Genomic variation, diseases and drugs
Bento, A. Patrícia
Gaulton, Anna
Hersey, Anne
Bellis, Louisa J.
Chambers, Jon
Davies, Mark
Krüger, Felix A.
Light, Yvonne
Mak, Lora
McGlinchey, Shaun
Nowotka, Michal
Papadatos, George
Santos, Rita
Overington, John P.
The ChEMBL bioactivity database: an update
title The ChEMBL bioactivity database: an update
title_full The ChEMBL bioactivity database: an update
title_fullStr The ChEMBL bioactivity database: an update
title_full_unstemmed The ChEMBL bioactivity database: an update
title_short The ChEMBL bioactivity database: an update
title_sort chembl bioactivity database: an update
topic VI. Genomic variation, diseases and drugs
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965067/
https://www.ncbi.nlm.nih.gov/pubmed/24214965
http://dx.doi.org/10.1093/nar/gkt1031
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