Endostar combined with radiotherapy increases radiation sensitivity by decreasing the expression of TGF-β1, HIF-1α and bFGF

The aim of the present study was to determine how Endostar inhibits tumor angiogenesis and increases radiation sensitivity when combined with radiotherapy. In vitro studies were conducted to analyze the expression levels of transforming growth factor-β1 (TGF-β1), hypoxia-inducible factor 1 (HIF-1α)...

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Detalles Bibliográficos
Autores principales: WU, YAOGUI, ZHENG, YONGFA, SHEN, ZHIXIANG, GE, WEI, XIE, YISHAN, LI, CHANGHU
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965127/
https://www.ncbi.nlm.nih.gov/pubmed/24669250
http://dx.doi.org/10.3892/etm.2014.1526
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author WU, YAOGUI
ZHENG, YONGFA
SHEN, ZHIXIANG
GE, WEI
XIE, YISHAN
LI, CHANGHU
author_facet WU, YAOGUI
ZHENG, YONGFA
SHEN, ZHIXIANG
GE, WEI
XIE, YISHAN
LI, CHANGHU
author_sort WU, YAOGUI
collection PubMed
description The aim of the present study was to determine how Endostar inhibits tumor angiogenesis and increases radiation sensitivity when combined with radiotherapy. In vitro studies were conducted to analyze the expression levels of transforming growth factor-β1 (TGF-β1), hypoxia-inducible factor 1 (HIF-1α) and basic fibroblast growth factor (bFGF) in lung adenocarcinoma A549 cells, using the antiangiogenesis drug Endostar combined with radiotherapy. In addition, lung adenocarcinoma A549 cell apoptosis was detected via Hoechst staining. The combination of Endostar with radiotherapy was investigated and the results indicated that this combination significantly inhibited tumor cell proliferation and TGF-β1, HIF-1α and bFGF expression. Changes in gene expression were found to promote apoptosis, thus, enhancing the inhibition of tumor angiogenesis and ultimately inhibiting tumor cell growth, invasion and metastasis.
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spelling pubmed-39651272014-03-25 Endostar combined with radiotherapy increases radiation sensitivity by decreasing the expression of TGF-β1, HIF-1α and bFGF WU, YAOGUI ZHENG, YONGFA SHEN, ZHIXIANG GE, WEI XIE, YISHAN LI, CHANGHU Exp Ther Med Articles The aim of the present study was to determine how Endostar inhibits tumor angiogenesis and increases radiation sensitivity when combined with radiotherapy. In vitro studies were conducted to analyze the expression levels of transforming growth factor-β1 (TGF-β1), hypoxia-inducible factor 1 (HIF-1α) and basic fibroblast growth factor (bFGF) in lung adenocarcinoma A549 cells, using the antiangiogenesis drug Endostar combined with radiotherapy. In addition, lung adenocarcinoma A549 cell apoptosis was detected via Hoechst staining. The combination of Endostar with radiotherapy was investigated and the results indicated that this combination significantly inhibited tumor cell proliferation and TGF-β1, HIF-1α and bFGF expression. Changes in gene expression were found to promote apoptosis, thus, enhancing the inhibition of tumor angiogenesis and ultimately inhibiting tumor cell growth, invasion and metastasis. D.A. Spandidos 2014-04 2014-02-07 /pmc/articles/PMC3965127/ /pubmed/24669250 http://dx.doi.org/10.3892/etm.2014.1526 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
WU, YAOGUI
ZHENG, YONGFA
SHEN, ZHIXIANG
GE, WEI
XIE, YISHAN
LI, CHANGHU
Endostar combined with radiotherapy increases radiation sensitivity by decreasing the expression of TGF-β1, HIF-1α and bFGF
title Endostar combined with radiotherapy increases radiation sensitivity by decreasing the expression of TGF-β1, HIF-1α and bFGF
title_full Endostar combined with radiotherapy increases radiation sensitivity by decreasing the expression of TGF-β1, HIF-1α and bFGF
title_fullStr Endostar combined with radiotherapy increases radiation sensitivity by decreasing the expression of TGF-β1, HIF-1α and bFGF
title_full_unstemmed Endostar combined with radiotherapy increases radiation sensitivity by decreasing the expression of TGF-β1, HIF-1α and bFGF
title_short Endostar combined with radiotherapy increases radiation sensitivity by decreasing the expression of TGF-β1, HIF-1α and bFGF
title_sort endostar combined with radiotherapy increases radiation sensitivity by decreasing the expression of tgf-β1, hif-1α and bfgf
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965127/
https://www.ncbi.nlm.nih.gov/pubmed/24669250
http://dx.doi.org/10.3892/etm.2014.1526
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