The paradox of conformational constraint in the design of Cbl(TKB)-binding peptides

Solving the crystal structure of Cbl(TKB) in complex with a pentapeptide, pYTPEP, revealed that the PEP region adopted a poly-L-proline type II (PPII) helix. An unnatural amino acid termed a proline-templated glutamic acid (ptE) that constrained both the backbone and sidechain to the bound conformat...

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Detalles Bibliográficos
Autores principales: Kumar, Eric A., Chen, Qianyi, Kizhake, Smitha, Kolar, Carol, Kang, Myungshim, Chang, Chia-en A., Borgstahl, Gloria E. O., Natarajan, Amarnath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965358/
https://www.ncbi.nlm.nih.gov/pubmed/23572190
http://dx.doi.org/10.1038/srep01639

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