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A High Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of gsp

Mis-sense mutations in the α-subunit of the G-protein, G(s)α, cause fibrous dysplasia of bone/McCune-Albright syndrome. The biochemical outcome of these mutations is constitutively active G(s)α and increased levels of cAMP. The aim of this study was to develop an assay system that would allow the id...

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Detalles Bibliográficos
Autores principales:	Bhattacharyya, Nisan, Hu, Xin, Chen, Catherine Z., Mathews Griner, Lesley A., Zheng, Wei, Inglese, James, Austin, Christopher P., Marugan, Juan J., Southall, Noel, Neumann, Susanne, Northup, John K., Ferrer, Marc, Collins, Michael T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965391/ https://www.ncbi.nlm.nih.gov/pubmed/24667240 http://dx.doi.org/10.1371/journal.pone.0090766

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