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FDA’s Nozzle Numerical Simulation Challenge: Non-Newtonian Fluid Effects and Blood Damage
Data from FDA’s nozzle challenge–a study to assess the suitability of simulating fluid flow in an idealized medical device–is used to validate the simulations obtained from a numerical, finite-differences code. Various physiological indicators are computed and compared with experimental data from th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965442/ https://www.ncbi.nlm.nih.gov/pubmed/24667931 http://dx.doi.org/10.1371/journal.pone.0092638 |
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author | Trias, Miquel Arbona, Antonio Massó, Joan Miñano, Borja Bona, Carles |
author_facet | Trias, Miquel Arbona, Antonio Massó, Joan Miñano, Borja Bona, Carles |
author_sort | Trias, Miquel |
collection | PubMed |
description | Data from FDA’s nozzle challenge–a study to assess the suitability of simulating fluid flow in an idealized medical device–is used to validate the simulations obtained from a numerical, finite-differences code. Various physiological indicators are computed and compared with experimental data from three different laboratories, getting a very good agreement. Special care is taken with the derivation of blood damage (hemolysis). The paper is focused on the laminar regime, in order to investigate non-Newtonian effects (non-constant fluid viscosity). The code can deal with these effects with just a small extra computational cost, improving Newtonian estimations up to a ten percent. The relevance of non-Newtonian effects for hemolysis parameters is discussed. |
format | Online Article Text |
id | pubmed-3965442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39654422014-03-27 FDA’s Nozzle Numerical Simulation Challenge: Non-Newtonian Fluid Effects and Blood Damage Trias, Miquel Arbona, Antonio Massó, Joan Miñano, Borja Bona, Carles PLoS One Research Article Data from FDA’s nozzle challenge–a study to assess the suitability of simulating fluid flow in an idealized medical device–is used to validate the simulations obtained from a numerical, finite-differences code. Various physiological indicators are computed and compared with experimental data from three different laboratories, getting a very good agreement. Special care is taken with the derivation of blood damage (hemolysis). The paper is focused on the laminar regime, in order to investigate non-Newtonian effects (non-constant fluid viscosity). The code can deal with these effects with just a small extra computational cost, improving Newtonian estimations up to a ten percent. The relevance of non-Newtonian effects for hemolysis parameters is discussed. Public Library of Science 2014-03-25 /pmc/articles/PMC3965442/ /pubmed/24667931 http://dx.doi.org/10.1371/journal.pone.0092638 Text en © 2014 Trias et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Trias, Miquel Arbona, Antonio Massó, Joan Miñano, Borja Bona, Carles FDA’s Nozzle Numerical Simulation Challenge: Non-Newtonian Fluid Effects and Blood Damage |
title | FDA’s Nozzle Numerical Simulation Challenge: Non-Newtonian Fluid Effects and Blood Damage |
title_full | FDA’s Nozzle Numerical Simulation Challenge: Non-Newtonian Fluid Effects and Blood Damage |
title_fullStr | FDA’s Nozzle Numerical Simulation Challenge: Non-Newtonian Fluid Effects and Blood Damage |
title_full_unstemmed | FDA’s Nozzle Numerical Simulation Challenge: Non-Newtonian Fluid Effects and Blood Damage |
title_short | FDA’s Nozzle Numerical Simulation Challenge: Non-Newtonian Fluid Effects and Blood Damage |
title_sort | fda’s nozzle numerical simulation challenge: non-newtonian fluid effects and blood damage |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965442/ https://www.ncbi.nlm.nih.gov/pubmed/24667931 http://dx.doi.org/10.1371/journal.pone.0092638 |
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