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Increased Risk of Benign Prostate Hyperplasia in Sleep Apnea Patients: A Nationwide Population-Based Study

BACKGROUND: Sleep apnea (SA) is a common sleep disorder characterized by chronic intermittent hypoxia (IH). Chronic IH induces systemic inflammatory processes, which can cause tissue damage and contribute to prostatic enlargement. The purpose of this study was to evaluate the association between ben...

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Autores principales: Chou, Ping-Song, Chang, Wei-Chiao, Chou, Wei-Po, Liu, Mu-En, Lai, Chiou-Lian, Liu, Ching-Kuan, Ku, Yan-Chiou, Tsai, Shih-Jen, Chou, Yii-Her, Chang, Wei-Pin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965509/
https://www.ncbi.nlm.nih.gov/pubmed/24667846
http://dx.doi.org/10.1371/journal.pone.0093081
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author Chou, Ping-Song
Chang, Wei-Chiao
Chou, Wei-Po
Liu, Mu-En
Lai, Chiou-Lian
Liu, Ching-Kuan
Ku, Yan-Chiou
Tsai, Shih-Jen
Chou, Yii-Her
Chang, Wei-Pin
author_facet Chou, Ping-Song
Chang, Wei-Chiao
Chou, Wei-Po
Liu, Mu-En
Lai, Chiou-Lian
Liu, Ching-Kuan
Ku, Yan-Chiou
Tsai, Shih-Jen
Chou, Yii-Her
Chang, Wei-Pin
author_sort Chou, Ping-Song
collection PubMed
description BACKGROUND: Sleep apnea (SA) is a common sleep disorder characterized by chronic intermittent hypoxia (IH). Chronic IH induces systemic inflammatory processes, which can cause tissue damage and contribute to prostatic enlargement. The purpose of this study was to evaluate the association between benign prostate hyperplasia (BPH) and SA in a Taiwanese population. METHODS: The study population was identified from Taiwan’s National Health Insurance Research Database (NHIRD) and contained 202 SA patients and 1010 control patients. The study cohort consisted of men aged ≥30 years who were newly diagnosed with SA between January 1997 and December 2005. Each patient was monitored for 5 years from the index date for the development of BPH. A Cox regression analysis was used to calculate the hazard ratios (HRs) for BPH in the SA and control patients. RESULTS: During the 5-year follow-up, 18 SA patients (8.9%) and 32 non-SA control patients (3.2%) developed BPH. The adjusted HR for BPH was 2.35-fold higher in the patients with SA than in the control patients (95% confidence interval (CI) 1.28–4.29, P<.01). We further divided the SA patients into 4 age groups. After adjusting for potential confounding factors, the highest adjusted HR for BPH in the SA patients compared with the control patients was 5.59 (95% CI = 2.19–14.31, P<.001) in the patients aged between 51 and 65 years. CONCLUSION: Our study results indicate that patients with SA are associated with increased longitudinal risk of BPH development, and that the effects of SA on BPH development are age-dependent.
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spelling pubmed-39655092014-03-27 Increased Risk of Benign Prostate Hyperplasia in Sleep Apnea Patients: A Nationwide Population-Based Study Chou, Ping-Song Chang, Wei-Chiao Chou, Wei-Po Liu, Mu-En Lai, Chiou-Lian Liu, Ching-Kuan Ku, Yan-Chiou Tsai, Shih-Jen Chou, Yii-Her Chang, Wei-Pin PLoS One Research Article BACKGROUND: Sleep apnea (SA) is a common sleep disorder characterized by chronic intermittent hypoxia (IH). Chronic IH induces systemic inflammatory processes, which can cause tissue damage and contribute to prostatic enlargement. The purpose of this study was to evaluate the association between benign prostate hyperplasia (BPH) and SA in a Taiwanese population. METHODS: The study population was identified from Taiwan’s National Health Insurance Research Database (NHIRD) and contained 202 SA patients and 1010 control patients. The study cohort consisted of men aged ≥30 years who were newly diagnosed with SA between January 1997 and December 2005. Each patient was monitored for 5 years from the index date for the development of BPH. A Cox regression analysis was used to calculate the hazard ratios (HRs) for BPH in the SA and control patients. RESULTS: During the 5-year follow-up, 18 SA patients (8.9%) and 32 non-SA control patients (3.2%) developed BPH. The adjusted HR for BPH was 2.35-fold higher in the patients with SA than in the control patients (95% confidence interval (CI) 1.28–4.29, P<.01). We further divided the SA patients into 4 age groups. After adjusting for potential confounding factors, the highest adjusted HR for BPH in the SA patients compared with the control patients was 5.59 (95% CI = 2.19–14.31, P<.001) in the patients aged between 51 and 65 years. CONCLUSION: Our study results indicate that patients with SA are associated with increased longitudinal risk of BPH development, and that the effects of SA on BPH development are age-dependent. Public Library of Science 2014-03-25 /pmc/articles/PMC3965509/ /pubmed/24667846 http://dx.doi.org/10.1371/journal.pone.0093081 Text en © 2014 Chou et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Chou, Ping-Song
Chang, Wei-Chiao
Chou, Wei-Po
Liu, Mu-En
Lai, Chiou-Lian
Liu, Ching-Kuan
Ku, Yan-Chiou
Tsai, Shih-Jen
Chou, Yii-Her
Chang, Wei-Pin
Increased Risk of Benign Prostate Hyperplasia in Sleep Apnea Patients: A Nationwide Population-Based Study
title Increased Risk of Benign Prostate Hyperplasia in Sleep Apnea Patients: A Nationwide Population-Based Study
title_full Increased Risk of Benign Prostate Hyperplasia in Sleep Apnea Patients: A Nationwide Population-Based Study
title_fullStr Increased Risk of Benign Prostate Hyperplasia in Sleep Apnea Patients: A Nationwide Population-Based Study
title_full_unstemmed Increased Risk of Benign Prostate Hyperplasia in Sleep Apnea Patients: A Nationwide Population-Based Study
title_short Increased Risk of Benign Prostate Hyperplasia in Sleep Apnea Patients: A Nationwide Population-Based Study
title_sort increased risk of benign prostate hyperplasia in sleep apnea patients: a nationwide population-based study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965509/
https://www.ncbi.nlm.nih.gov/pubmed/24667846
http://dx.doi.org/10.1371/journal.pone.0093081
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