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Overexpression of Nrf2 Protects against Microcystin-Induced Hepatotoxicity in Mice

Oxidative stress and glutathione (GSH) depletion are implicated in mycocystin hepatotoxicity. To investigate the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in microcystin-induced liver injury, Nrf2-null, wild-type, and Keap1-hepatocyte knockout (Keap1-HKO) mice were treated with micr...

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Detalles Bibliográficos
Autores principales:	Lu, Yuan-Fu, Liu, Jie, Wu, Kai Connie, Qu, Qiang, Fan, Fang, Klaassen, Curtis D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965536/ https://www.ncbi.nlm.nih.gov/pubmed/24667526 http://dx.doi.org/10.1371/journal.pone.0093013

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