First Susceptibility Testing of Mycobacterium tuberculosis for Second-line Anti-tuberculosis Drugs in Ghana

We performed drug susceptibility testing on first- and second-line drugs in Mycobacterium tuberculosis (M. tuberculosis) for the first time in Ghana to obtain preliminary data on drug-resistant tuberculosis. Of 21 isolates (4 new cases and 17 treated cases), 5 (23.8%) were multi-drug resistant tuber...

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Autores principales: Kato, Tomoko, Addo, Kennedy Kwasi, Nartey, Naomi, Nyarko, Alexander Kwadwo, Bonsu, Frank Adae, Mitarai, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Tropical Medicine 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965846/
https://www.ncbi.nlm.nih.gov/pubmed/24808747
http://dx.doi.org/10.2149/tmh.2013-16
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author Kato, Tomoko
Addo, Kennedy Kwasi
Nartey, Naomi
Nyarko, Alexander Kwadwo
Bonsu, Frank Adae
Mitarai, Satoshi
author_facet Kato, Tomoko
Addo, Kennedy Kwasi
Nartey, Naomi
Nyarko, Alexander Kwadwo
Bonsu, Frank Adae
Mitarai, Satoshi
author_sort Kato, Tomoko
collection PubMed
description We performed drug susceptibility testing on first- and second-line drugs in Mycobacterium tuberculosis (M. tuberculosis) for the first time in Ghana to obtain preliminary data on drug-resistant tuberculosis. Of 21 isolates (4 new cases and 17 treated cases), 5 (23.8%) were multi-drug resistant tuberculosis (MDR-TB) and 19 (90.5%) were resistant to at least one drug, but no extensively drug-resistant TB (XDR-TB) was identified. Since the target patients were Category II, IV or smear positive at follow-up microscopy, it is understandable that there were many drug-resistant TB cases. Six isolates were resistant to one or two second-line drugs, but the second-line drugs were not approved in Ghana. It is considered that the bacilli were imported from abroad. Preventing the import of drug-resistant TB bacilli is probably one of best ways to control TB in Ghana.
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spelling pubmed-39658462014-05-07 First Susceptibility Testing of Mycobacterium tuberculosis for Second-line Anti-tuberculosis Drugs in Ghana Kato, Tomoko Addo, Kennedy Kwasi Nartey, Naomi Nyarko, Alexander Kwadwo Bonsu, Frank Adae Mitarai, Satoshi Trop Med Health Short Communication We performed drug susceptibility testing on first- and second-line drugs in Mycobacterium tuberculosis (M. tuberculosis) for the first time in Ghana to obtain preliminary data on drug-resistant tuberculosis. Of 21 isolates (4 new cases and 17 treated cases), 5 (23.8%) were multi-drug resistant tuberculosis (MDR-TB) and 19 (90.5%) were resistant to at least one drug, but no extensively drug-resistant TB (XDR-TB) was identified. Since the target patients were Category II, IV or smear positive at follow-up microscopy, it is understandable that there were many drug-resistant TB cases. Six isolates were resistant to one or two second-line drugs, but the second-line drugs were not approved in Ghana. It is considered that the bacilli were imported from abroad. Preventing the import of drug-resistant TB bacilli is probably one of best ways to control TB in Ghana. The Japanese Society of Tropical Medicine 2014-03 2014-02-04 /pmc/articles/PMC3965846/ /pubmed/24808747 http://dx.doi.org/10.2149/tmh.2013-16 Text en © 2014 Japanese Society of Tropical Medicine This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Kato, Tomoko
Addo, Kennedy Kwasi
Nartey, Naomi
Nyarko, Alexander Kwadwo
Bonsu, Frank Adae
Mitarai, Satoshi
First Susceptibility Testing of Mycobacterium tuberculosis for Second-line Anti-tuberculosis Drugs in Ghana
title First Susceptibility Testing of Mycobacterium tuberculosis for Second-line Anti-tuberculosis Drugs in Ghana
title_full First Susceptibility Testing of Mycobacterium tuberculosis for Second-line Anti-tuberculosis Drugs in Ghana
title_fullStr First Susceptibility Testing of Mycobacterium tuberculosis for Second-line Anti-tuberculosis Drugs in Ghana
title_full_unstemmed First Susceptibility Testing of Mycobacterium tuberculosis for Second-line Anti-tuberculosis Drugs in Ghana
title_short First Susceptibility Testing of Mycobacterium tuberculosis for Second-line Anti-tuberculosis Drugs in Ghana
title_sort first susceptibility testing of mycobacterium tuberculosis for second-line anti-tuberculosis drugs in ghana
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965846/
https://www.ncbi.nlm.nih.gov/pubmed/24808747
http://dx.doi.org/10.2149/tmh.2013-16
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