Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer

This perspective article highlights the leukocyte-cancer cell hybrid theory as a mechanism for cancer metastasis. Beginning from the first proposal of the theory more than a century ago and continuing today with the first proof for this theory in a human cancer, the hybrid theory offers a unifying e...

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Detalles Bibliográficos
Autor principal: Pawelek, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966146/
https://www.ncbi.nlm.nih.gov/pubmed/24589183
http://dx.doi.org/10.5732/cjc.013.10243
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author Pawelek, John M.
author_facet Pawelek, John M.
author_sort Pawelek, John M.
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description This perspective article highlights the leukocyte-cancer cell hybrid theory as a mechanism for cancer metastasis. Beginning from the first proposal of the theory more than a century ago and continuing today with the first proof for this theory in a human cancer, the hybrid theory offers a unifying explanation for metastasis. In this scenario, leukocyte fusion with a cancer cell is a secondary disease superimposed upon the early tumor, giving birth to a new, malignant cell with a leukocyte-cancer cell hybrid epigenome.
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spelling pubmed-39661462014-03-26 Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer Pawelek, John M. Chin J Cancer Review This perspective article highlights the leukocyte-cancer cell hybrid theory as a mechanism for cancer metastasis. Beginning from the first proposal of the theory more than a century ago and continuing today with the first proof for this theory in a human cancer, the hybrid theory offers a unifying explanation for metastasis. In this scenario, leukocyte fusion with a cancer cell is a secondary disease superimposed upon the early tumor, giving birth to a new, malignant cell with a leukocyte-cancer cell hybrid epigenome. Sun Yat-sen University Cancer Center 2014-03 /pmc/articles/PMC3966146/ /pubmed/24589183 http://dx.doi.org/10.5732/cjc.013.10243 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Review
Pawelek, John M.
Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer
title Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer
title_full Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer
title_fullStr Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer
title_full_unstemmed Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer
title_short Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer
title_sort fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966146/
https://www.ncbi.nlm.nih.gov/pubmed/24589183
http://dx.doi.org/10.5732/cjc.013.10243
work_keys_str_mv AT pawelekjohnm fusionofbonemarrowderivedcellswithcancercellsmetastasisasasecondarydiseaseincancer

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