Cargando…

Genomic and Population-Level Effects of Gene Conversion in Caenorhabditis Paralogs

Interlocus gene conversion, the nonreciprocal exchange of genetic material between genes, is facilitated by high levels of sequence identity between DNA sequences and has the dual effect of homogenizing intergenic sequences while increasing intragenic variation. Gene conversion can have important co...

Descripción completa

Detalles Bibliográficos
Autores principales: Katju, Vaishali, Bergthorsson, Ulfar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966223/
https://www.ncbi.nlm.nih.gov/pubmed/24710096
http://dx.doi.org/10.3390/genes1030452
_version_ 1782308878889779200
author Katju, Vaishali
Bergthorsson, Ulfar
author_facet Katju, Vaishali
Bergthorsson, Ulfar
author_sort Katju, Vaishali
collection PubMed
description Interlocus gene conversion, the nonreciprocal exchange of genetic material between genes, is facilitated by high levels of sequence identity between DNA sequences and has the dual effect of homogenizing intergenic sequences while increasing intragenic variation. Gene conversion can have important consequences for the evolution of paralogs subsequent to gene duplication, as well as result in misinterpretations regarding their evolution. We review the current state of research on gene conversion in paralogs within Caenorhabditis elegans and its congeneric species, including the relative rates of gene conversion, the range of observable conversion tracts, the genomic variables that strongly influence the frequency of gene conversion and its contribution to concerted evolution of multigene families. Additionally, we discuss recent studies that examine the phenotypic and population-genetic effects of interlocus gene conversion between the sex-determination locus fog-2 and its paralog ftr-1 in natural and experimental populations of C. elegans. In light of the limitations of gene conversion detection methods that rely solely on the statistical distribution of identical nucleotides between paralogs, we suggest that analyses of gene conversion in C. elegans take advantage of mutation accumulation experiments and sequencing projects of related Caenorhabditis species.
format Online
Article
Text
id pubmed-3966223
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-39662232014-03-26 Genomic and Population-Level Effects of Gene Conversion in Caenorhabditis Paralogs Katju, Vaishali Bergthorsson, Ulfar Genes (Basel) Review Interlocus gene conversion, the nonreciprocal exchange of genetic material between genes, is facilitated by high levels of sequence identity between DNA sequences and has the dual effect of homogenizing intergenic sequences while increasing intragenic variation. Gene conversion can have important consequences for the evolution of paralogs subsequent to gene duplication, as well as result in misinterpretations regarding their evolution. We review the current state of research on gene conversion in paralogs within Caenorhabditis elegans and its congeneric species, including the relative rates of gene conversion, the range of observable conversion tracts, the genomic variables that strongly influence the frequency of gene conversion and its contribution to concerted evolution of multigene families. Additionally, we discuss recent studies that examine the phenotypic and population-genetic effects of interlocus gene conversion between the sex-determination locus fog-2 and its paralog ftr-1 in natural and experimental populations of C. elegans. In light of the limitations of gene conversion detection methods that rely solely on the statistical distribution of identical nucleotides between paralogs, we suggest that analyses of gene conversion in C. elegans take advantage of mutation accumulation experiments and sequencing projects of related Caenorhabditis species. MDPI 2010-12-09 /pmc/articles/PMC3966223/ /pubmed/24710096 http://dx.doi.org/10.3390/genes1030452 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Katju, Vaishali
Bergthorsson, Ulfar
Genomic and Population-Level Effects of Gene Conversion in Caenorhabditis Paralogs
title Genomic and Population-Level Effects of Gene Conversion in Caenorhabditis Paralogs
title_full Genomic and Population-Level Effects of Gene Conversion in Caenorhabditis Paralogs
title_fullStr Genomic and Population-Level Effects of Gene Conversion in Caenorhabditis Paralogs
title_full_unstemmed Genomic and Population-Level Effects of Gene Conversion in Caenorhabditis Paralogs
title_short Genomic and Population-Level Effects of Gene Conversion in Caenorhabditis Paralogs
title_sort genomic and population-level effects of gene conversion in caenorhabditis paralogs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966223/
https://www.ncbi.nlm.nih.gov/pubmed/24710096
http://dx.doi.org/10.3390/genes1030452
work_keys_str_mv AT katjuvaishali genomicandpopulationleveleffectsofgeneconversionincaenorhabditisparalogs
AT bergthorssonulfar genomicandpopulationleveleffectsofgeneconversionincaenorhabditisparalogs