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Type IV collagen α1-chain noncollagenous domain blocks MMP-2 activation both in-vitro and in-vivo

α1(IV)NC1 inhibits angiogenesis by regulating MAPK activation, this biological function was partly attributed α1(IV)NC1 binding to α1β1-integrin. However, its potent antiangiogenic activity and the molecular targets of α1(IV)NC1 has not been investigated. In the present study, the regulation of MMP-...

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Detalles Bibliográficos
Autores principales:	Sudhakar, Yakkanti Akul, Verma, Raj Kumar, Pawar, Smita C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966261/ https://www.ncbi.nlm.nih.gov/pubmed/24670518 http://dx.doi.org/10.1038/srep04136

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