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Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration
Dendritic cells (DCs) are highly efficient antigen-presenting cells. The migratory properties of DCs give them the capacity to be a sentinel of the body and the vital role in the induction and regulation of adaptive immune responses. Therefore, it is important to understand the mechanisms in control...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966334/ https://www.ncbi.nlm.nih.gov/pubmed/24734242 http://dx.doi.org/10.1155/2014/738253 |
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author | Liu, Yuan Shi, Guixiu |
author_facet | Liu, Yuan Shi, Guixiu |
author_sort | Liu, Yuan |
collection | PubMed |
description | Dendritic cells (DCs) are highly efficient antigen-presenting cells. The migratory properties of DCs give them the capacity to be a sentinel of the body and the vital role in the induction and regulation of adaptive immune responses. Therefore, it is important to understand the mechanisms in control of migration of DCs to lymphoid and nonlymphoid tissues. This may provide us novel insight into the clinical treatment of diseases such as autoimmune disease, infectious disease, and tumor. The chemotactic G protein-coupled receptors (GPCR) play a vital role in control of DCs migration. Here, we reviewed the recent advances regarding the role of GPCR in control of migration of subsets of DCs, with a focus on the chemokine receptors. Understanding subsets of DCs migration could provide a rational basis for the design of novel therapies in various clinical conditions. |
format | Online Article Text |
id | pubmed-3966334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39663342014-04-14 Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration Liu, Yuan Shi, Guixiu Biomed Res Int Review Article Dendritic cells (DCs) are highly efficient antigen-presenting cells. The migratory properties of DCs give them the capacity to be a sentinel of the body and the vital role in the induction and regulation of adaptive immune responses. Therefore, it is important to understand the mechanisms in control of migration of DCs to lymphoid and nonlymphoid tissues. This may provide us novel insight into the clinical treatment of diseases such as autoimmune disease, infectious disease, and tumor. The chemotactic G protein-coupled receptors (GPCR) play a vital role in control of DCs migration. Here, we reviewed the recent advances regarding the role of GPCR in control of migration of subsets of DCs, with a focus on the chemokine receptors. Understanding subsets of DCs migration could provide a rational basis for the design of novel therapies in various clinical conditions. Hindawi Publishing Corporation 2014 2014-03-10 /pmc/articles/PMC3966334/ /pubmed/24734242 http://dx.doi.org/10.1155/2014/738253 Text en Copyright © 2014 Y. Liu and G. Shi. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Liu, Yuan Shi, Guixiu Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration |
title | Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration |
title_full | Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration |
title_fullStr | Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration |
title_full_unstemmed | Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration |
title_short | Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration |
title_sort | role of g protein-coupled receptors in control of dendritic cell migration |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966334/ https://www.ncbi.nlm.nih.gov/pubmed/24734242 http://dx.doi.org/10.1155/2014/738253 |
work_keys_str_mv | AT liuyuan roleofgproteincoupledreceptorsincontrolofdendriticcellmigration AT shiguixiu roleofgproteincoupledreceptorsincontrolofdendriticcellmigration |