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Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration

Dendritic cells (DCs) are highly efficient antigen-presenting cells. The migratory properties of DCs give them the capacity to be a sentinel of the body and the vital role in the induction and regulation of adaptive immune responses. Therefore, it is important to understand the mechanisms in control...

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Detalles Bibliográficos
Autores principales: Liu, Yuan, Shi, Guixiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966334/
https://www.ncbi.nlm.nih.gov/pubmed/24734242
http://dx.doi.org/10.1155/2014/738253
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author Liu, Yuan
Shi, Guixiu
author_facet Liu, Yuan
Shi, Guixiu
author_sort Liu, Yuan
collection PubMed
description Dendritic cells (DCs) are highly efficient antigen-presenting cells. The migratory properties of DCs give them the capacity to be a sentinel of the body and the vital role in the induction and regulation of adaptive immune responses. Therefore, it is important to understand the mechanisms in control of migration of DCs to lymphoid and nonlymphoid tissues. This may provide us novel insight into the clinical treatment of diseases such as autoimmune disease, infectious disease, and tumor. The chemotactic G protein-coupled receptors (GPCR) play a vital role in control of DCs migration. Here, we reviewed the recent advances regarding the role of GPCR in control of migration of subsets of DCs, with a focus on the chemokine receptors. Understanding subsets of DCs migration could provide a rational basis for the design of novel therapies in various clinical conditions.
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spelling pubmed-39663342014-04-14 Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration Liu, Yuan Shi, Guixiu Biomed Res Int Review Article Dendritic cells (DCs) are highly efficient antigen-presenting cells. The migratory properties of DCs give them the capacity to be a sentinel of the body and the vital role in the induction and regulation of adaptive immune responses. Therefore, it is important to understand the mechanisms in control of migration of DCs to lymphoid and nonlymphoid tissues. This may provide us novel insight into the clinical treatment of diseases such as autoimmune disease, infectious disease, and tumor. The chemotactic G protein-coupled receptors (GPCR) play a vital role in control of DCs migration. Here, we reviewed the recent advances regarding the role of GPCR in control of migration of subsets of DCs, with a focus on the chemokine receptors. Understanding subsets of DCs migration could provide a rational basis for the design of novel therapies in various clinical conditions. Hindawi Publishing Corporation 2014 2014-03-10 /pmc/articles/PMC3966334/ /pubmed/24734242 http://dx.doi.org/10.1155/2014/738253 Text en Copyright © 2014 Y. Liu and G. Shi. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Liu, Yuan
Shi, Guixiu
Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration
title Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration
title_full Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration
title_fullStr Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration
title_full_unstemmed Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration
title_short Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration
title_sort role of g protein-coupled receptors in control of dendritic cell migration
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966334/
https://www.ncbi.nlm.nih.gov/pubmed/24734242
http://dx.doi.org/10.1155/2014/738253
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