Phenytoin Toxicity from Cocaine Adulteration

The use of phenytoin (PHT) as a cocaine adulterant was reported decades ago; that practice is still current. Ironically PHT has also been used for the treatment of cocaine dependence. A drug smuggler developed PHT toxicity after swallowing several rocks of crack. We investigated the current trends o...

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Detalles Bibliográficos
Autor principal: Roldan, Carlos J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Department of Emergency Medicine, University of California, Irvine School of Medicine 2014
Materias:
Diagnostic Acumen
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966464/
https://www.ncbi.nlm.nih.gov/pubmed/24672596
http://dx.doi.org/10.5811/westjem.2013.12.20010
Descripción
Sumario:The use of phenytoin (PHT) as a cocaine adulterant was reported decades ago; that practice is still current. Ironically PHT has also been used for the treatment of cocaine dependence. A drug smuggler developed PHT toxicity after swallowing several rocks of crack. We investigated the current trends of PHT as a cocaine adulterant and its toxicological implications. We also reviewed the clinical use of PTH in relation to cocaine. The use of PHT as cocaine cut is a current practice. This may affect the clinical manifestations and the management of the cocaine-related visits to the emergency department.

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