Phenytoin Toxicity from Cocaine Adulteration

The use of phenytoin (PHT) as a cocaine adulterant was reported decades ago; that practice is still current. Ironically PHT has also been used for the treatment of cocaine dependence. A drug smuggler developed PHT toxicity after swallowing several rocks of crack. We investigated the current trends o...

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Detalles Bibliográficos
Autor principal: Roldan, Carlos J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Department of Emergency Medicine, University of California, Irvine School of Medicine 2014
Materias:
Diagnostic Acumen
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966464/
https://www.ncbi.nlm.nih.gov/pubmed/24672596
http://dx.doi.org/10.5811/westjem.2013.12.20010
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author Roldan, Carlos J.
author_facet Roldan, Carlos J.
author_sort Roldan, Carlos J.
collection PubMed
description The use of phenytoin (PHT) as a cocaine adulterant was reported decades ago; that practice is still current. Ironically PHT has also been used for the treatment of cocaine dependence. A drug smuggler developed PHT toxicity after swallowing several rocks of crack. We investigated the current trends of PHT as a cocaine adulterant and its toxicological implications. We also reviewed the clinical use of PTH in relation to cocaine. The use of PHT as cocaine cut is a current practice. This may affect the clinical manifestations and the management of the cocaine-related visits to the emergency department.
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spelling pubmed-39664642014-03-26 Phenytoin Toxicity from Cocaine Adulteration Roldan, Carlos J. West J Emerg Med Diagnostic Acumen The use of phenytoin (PHT) as a cocaine adulterant was reported decades ago; that practice is still current. Ironically PHT has also been used for the treatment of cocaine dependence. A drug smuggler developed PHT toxicity after swallowing several rocks of crack. We investigated the current trends of PHT as a cocaine adulterant and its toxicological implications. We also reviewed the clinical use of PTH in relation to cocaine. The use of PHT as cocaine cut is a current practice. This may affect the clinical manifestations and the management of the cocaine-related visits to the emergency department. Department of Emergency Medicine, University of California, Irvine School of Medicine 2014-03 /pmc/articles/PMC3966464/ /pubmed/24672596 http://dx.doi.org/10.5811/westjem.2013.12.20010 Text en Copyright © 2014 the authors. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) License. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Diagnostic Acumen
Roldan, Carlos J.
Phenytoin Toxicity from Cocaine Adulteration
title Phenytoin Toxicity from Cocaine Adulteration
title_full Phenytoin Toxicity from Cocaine Adulteration
title_fullStr Phenytoin Toxicity from Cocaine Adulteration
title_full_unstemmed Phenytoin Toxicity from Cocaine Adulteration
title_short Phenytoin Toxicity from Cocaine Adulteration
title_sort phenytoin toxicity from cocaine adulteration
topic Diagnostic Acumen
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966464/
https://www.ncbi.nlm.nih.gov/pubmed/24672596
http://dx.doi.org/10.5811/westjem.2013.12.20010
work_keys_str_mv AT roldancarlosj phenytointoxicityfromcocaineadulteration

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