Genetic variation in COMT activity impacts learning and dopamine release capacity in the striatum

A common genetic polymorphism that results in increased activity of the dopamine regulating enzyme COMT (the COMT Val(158) allele) has been found to associate with poorer cognitive performance and increased susceptibility to develop psychiatric disorders. It is generally assumed that this increase i...

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Detalles Bibliográficos
Autores principales: Simpson, Eleanor H., Morud, Julia, Winiger, Vanessa, Biezonski, Dominik, Zhu, Judy P., Bach, Mary Elizabeth, Malleret, Gael, Polan, H. Jonathan, Ng-Evans, Scott, Phillips, Paul E.M., Kellendonk, Christoph, Kandel, Eric R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966542/
https://www.ncbi.nlm.nih.gov/pubmed/24639487
http://dx.doi.org/10.1101/lm.032094.113

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