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Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity

Autosomal dominant Stargardt-like macular dystrophy (STGD3) in humans results from mutations in elongation of very long chain FAs-like 4 (ELOVL4), which leads to vision loss in young adults. ELOVL4 is an integral endoplasmic reticulum (ER) protein that mediates the elongation of very long chain (VLC...

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Detalles Bibliográficos
Autores principales:	Logan, Sreemathi, Agbaga, Martin-Paul, Chan, Michael D., Brush, Richard S., Anderson, Robert E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2014
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966703/ https://www.ncbi.nlm.nih.gov/pubmed/24569140 http://dx.doi.org/10.1194/jlr.M045443

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