A Novel Artificial MicroRNA Expressing AAV Vector for Phospholamban Silencing in Cardiomyocytes Improves Ca(2+) Uptake into the Sarcoplasmic Reticulum

In failing rat hearts, post-transcriptonal inhibition of phospholamban (PLB) expression by AAV9 vector-mediated cardiac delivery of short hairpin RNAs directed against PLB (shPLBr) improves both impaired SERCA2a controlled Ca(2+) cycling and contractile dysfunction. Cardiac delivery of shPLB, howeve...

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Detalles Bibliográficos
Autores principales: Größl, Tobias, Hammer, Elke, Bien-Möller, Sandra, Geisler, Anja, Pinkert, Sandra, Röger, Carsten, Poller, Wolfgang, Kurreck, Jens, Völker, Uwe, Vetter, Roland, Fechner, Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966758/
https://www.ncbi.nlm.nih.gov/pubmed/24670775
http://dx.doi.org/10.1371/journal.pone.0092188

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