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Molecular Topology as Novel Strategy for Discovery of Drugs with Aβ Lowering and Anti-Aggregation Dual Activities for Alzheimer’s Disease

BACKGROUND AND PURPOSE: In this study, we demonstrate the use of Molecular topology (MT) in an Alzheimer’s disease (AD) drug discovery program. MT uses and expands upon the principles governing the molecular connectivity theory of numerically characterizing molecular structures, in the present case,...

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Detalles Bibliográficos
Autores principales:	Wang, Jun, Land, David, Ono, Kenjiro, Galvez, Jorge, Zhao, Wei, Vempati, Prashant, Steele, John W., Cheng, Alice, Yamada, Masahito, Levine, Samara, Mazzola, Paolo, Pasinetti, Giulio M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966818/ https://www.ncbi.nlm.nih.gov/pubmed/24671215 http://dx.doi.org/10.1371/journal.pone.0092750

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