Diminished WNT → β-catenin → c-MYC signaling is a barrier for malignant progression of BRAF(V600E)-induced lung tumors

Oncogene-induced senescence (OIS) is proposed as a cellular defense mechanism that restrains malignant progression of oncogene-expressing, initiated tumor cells. Consistent with this, expression of BRAF(V600E) in the mouse lung epithelium elicits benign tumors that fail to progress to cancer due to...

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Detalles Bibliográficos
Autores principales: Juan, Joseph, Muraguchi, Teruyuki, Iezza, Gioia, Sears, Rosalie C., McMahon, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967046/
https://www.ncbi.nlm.nih.gov/pubmed/24589553
http://dx.doi.org/10.1101/gad.233627.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967046/
https://www.ncbi.nlm.nih.gov/pubmed/24589553
http://dx.doi.org/10.1101/gad.233627.113

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