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Diminished WNT → β-catenin → c-MYC signaling is a barrier for malignant progression of BRAF(V600E)-induced lung tumors
Oncogene-induced senescence (OIS) is proposed as a cellular defense mechanism that restrains malignant progression of oncogene-expressing, initiated tumor cells. Consistent with this, expression of BRAF(V600E) in the mouse lung epithelium elicits benign tumors that fail to progress to cancer due to...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967046/ https://www.ncbi.nlm.nih.gov/pubmed/24589553 http://dx.doi.org/10.1101/gad.233627.113 |